Diabetes

Findings from Yale University Broaden Understanding of Diabetes

Published in Obesity and Diabetes Week, March 26th, 2012

2012 MAR 26 -- "Development of type 1 diabetes in the nonobese diabetic (NOD) mouse is preceded by an immune cell infiltrate in the pancreatic islets. The exact role of the attracted cells is still poorly understood," scientists writing in the journal Proceedings of the National Academy of Sciences of the United States of America report.

"Chemokine CCL2/MCP-1 is known to attract CCR2(+) monocytes and dendritic cells (DCs). We have previously shown that transgenic expression of CCL2 in pancreatic islets via the rat insulin promoter induces nondestructive insulitis on a nonautoimmune background. We report here an unexpected reduction of diabetes...

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Source: Obesity and Diabetes Week (2012-03-26)

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