Cytoplasmic and Nuclear Receptors

Research Reports from National Research Council Provide New Insights into Cytoplasmic and Nuclear Receptors

Published in Obesity and Diabetes Week, April 30th, 2012

2012 APR 30 -- According to the authors of recent research from Rome, Italy, "PPARs are transcription factors that govern lipid and glucose homeostasis and play a central role in cardiovascular disease, obesity, and diabetes."

"Thus, there is significant interest in developing new agonists for these receptors. Given that the introduction of fluorine generally has a profound effect on the physical and/or biological properties of the target molecule, we synthesized a series of fluorinated analogs of the previously reported compound 2, some of which turned out to be remarkable PPAR alpha and PPAR gamma dual agonists," wrote G. Fracchiolla and colleagues,...

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Source: Obesity and Diabetes Week (2012-04-30)

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