Linkoping University
BRAF and KRAS gene mutations drive colorectal adenocarcinoma formation
Published in Oncology Business Week, May 30th, 2004
According to published research from Sweden, "colorectal cancer is a multistep process characterized by a sequence of genetic alterations in cell growth regulatory genes, such as the adenomatous polyposis coli, KRAS, p53 and DCC genes. In the present study mutation analysis was performed with SSCA/direct sequencing of the hot-spot regions in exons 11 and 15 for the BRAF gene and exons 1-2 for the KRAS gene in 130 primary colorectal cancer tumors and correlated with clinico-pathological and mutational data. We also performed mutation analysis of the corresponding conserved regions in the ARAF and...
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