Netherlands Cancer Institute
In vivo bioluminescence imaging reveals tumor elements in animal models
Published in Oncology Business Week, June 27th, 2004
"Animal tumor models using orthotopic tumors for the evaluation of cancer therapies are of greater clinical relevance than subcutaneous models, but they also pose greater difficulties for measuring tumor size and quantifying response to treatment. In this study, we used noninvasive bioluminescence imaging to monitor the intraperitoneal growth of luciferase-transfected CC531 colorectal cells in adult WAG/RIJ rats. The bioluminescence signal correlated well with post-mortem assessment of tumor load by visual inspection of the peritoneal cavity at specific follow-up times," scientists in Netherlands...
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