Kanazawa University

S100A4 expression prognostic indicator in invasive and metastatic oral SCCs

Published in Oncology Business Week, July 4th, 2004

S100A4 expression may be a prognostic indicator in invasive and metastatic oral squamous cell carcinoma.

"S100A4 is known to be involved in cancer cell motility by virtue of its ability to activate non-muscle myosin. In the current study, we investigated the interrelationship of clinico-pathological findings and S100A4 expression in oral squamous cell carcinoma (SCC). The expression of S100A4 was examined immunohistochemically in 41 clinical specimens of oral SCC," wrote investigators in Japan.

"S100A4 expression was detected in 11 (26.8%) of 41 cases. Although the expression of S100A4 was not associated with the primary tumor site and degree of...

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Source: Oncology Business Week (2004-07-04)

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