Jikei University Hospital

CD2+ tetraploid APL variant with double (15;17) translocations reported

Published in Oncology Business Week, April 3rd, 2005

A patient has been reported with a variant form of CD2+ acute promyelocytic leukemia with double (15;17) translocations.

Recent research published in the International Journal of Hematology reports of "a patient with a variant form of CD2+ acute promyelocytic leukemia (APL) who had double translocations (15;17) in a single leukemic cell. The patient presented with severe neutropenia, thrombocylopenia, and disseminated intravascular coagulation."

"The bone marrow showed marked hyperplasia with large leukemic cells that had bizarre nuclear configuration and basophilic, hypogranular cytoplasm. Leukemic cells were positive for CD2, 13, 33, 341,...

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Source: Oncology Business Week (2005-04-03)

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