Published in Oncology Business Week, January 29th, 2006
"Choline kinase is overexpressed in breast cancer cells and activated by oncogenes and mitogenic signals, making it a potential target for cancer therapy," wrote K. Glunde and colleagues, Johns Hopkins University.
"Here, we have examined, for the first time, the effects of RNA interference (RNAi) mediated down-regulation of choline kinase in nonmalignant and malignant human breast epithelial cell lines using magnetic resonance spectroscopy (MRS) as well as molecular...
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