European Institute of Oncology, Milan
HectH9 regulates transcriptional activation and tumor cell proliferation
Published in Oncology Business Week, January 29th, 2006
According to recent research published in the journal Cell, "The Myc oncoprotein forms a binary activating complex with its partner protein, Max, and a ternary repressive complex that, in addition to Max, contains the zinc finger protein Miz1. Here we show that the E3 ubiquitin ligase HectH9 ubiquitinates Myc in vivo and in vitro, forming a lysine 63-linked polyubiquitin chain. Miz1 inhibits this ubiquitination."
"HectH9-mediated ubiquitination of Myc is required for transactivation of multiple target genes, recruitment...
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