Angiogenesis
New angiogenesis study findings have been reported by scientists at MedImmune, Inc.
Published in Oncology Business Week, January 21st, 2007
Scientists discuss in "Direct targeting of alphavbeta3 integrin on tumor cells with a monoclonal antibody, Abegrin" new findings in angiogenesis. According to recent research from the United States, "The humanized monoclonal antibody Abegrin, currently in phase II trials for treatment of solid tumors, specifically recognizes the integrin alphavbeta3. Due to its high expression on mature osteoclasts, angiogenic endothelial cells, and tumor cells, integrin alphavbeta3 functions in several pathologic processes important to tumor growth and metastasis."
"Targeting of this integrin with Abegrin results in antitumor, antiangiogenic, and antiosteolytic activities. Here, we...
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