Chronic Lymphocytic Leukemia Genetics
Studies from Dana-Farber Cancer Institute, Department of Medical Oncology in the area of chronic lymphocytic leukemia genetics published
Published in Oncology Business Week, February 25th, 2007
Current study results from the report, "Chronic lymphocytic leukemia requires BCL2 to sequester prodeath BIM, explaining sensitivity to BCL2 antagonist ABT-737," have been published. "Antiapoptotic B cell leukemia/lymphoma 2 (BCL2) family proteins are expressed in many cancers, but the circumstances under which these proteins are necessary for tumor maintenance are poorly understood. We exploited a novel functional assay that uses BCL2 homology domain 3 (BH3) peptides to predict dependence on antiapoptotic proteins, a strategy we call BH3 profiling," researchers in the United States report.
"BH3 profiling accurately predicts sensitivity to BCL2 antagonist ABT-737 in...
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