Breast Cancer Therapy
Data on breast cancer therapy discussed by researchers at GlaxoSmithKline, Department of Oncology
Published in Oncology Business Week, March 4th, 2007
Data detailed in "Lapatinib antitumor activity is not dependent upon phosphatase and tensin homologue deleted on chromosome 10 in ErbB2-overexpressing breast cancers" have been presented. According to recent research from the United States, "Trastuzumab antitumor activity in ErbB2-overexpressing breast cancers seems to be dependent upon the presence of phosphatase and tensin homologue deleted on chromosome 10 (PTEN), a phosphatase that dampens phosphatidylinositol 3-kinase-Akt signaling. Consequently, PTEN deficiency, which occurs in 50% of breast cancers, predicts for resistance to trastuzumab monotherapy."
"Here, we show that lapatinib, a small-molecule inhibitor of...
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