Enzyme Research
Data on enzyme research discussed by researchers at Dana-Farber Cancer Institute, Department of Pediatric Oncology
Published in Oncology Business Week, February 10th, 2008
New research, 'Uniform sensitivity of FLT3 activation loop mutants to the tyrosine kinase inhibitor midostaurin,' is the subject of a report. According to recent research published in the journal Blood, "Small molecule inhibitors that target fms-like tyrosine kinase 3 (FLT3)-activating mutations have potential in the treatment of leukemias. However, certain mutations can simultaneously activate the tyrosine kinase, and confer resistance to small molecule inhibitors."
"We therefore tested the sensitivity of 8 FLT3 activation loop mutants to midostaurin. Each mutant conferred IL-3 factor-independent proliferation to Ba/F3 cells, and each resulted in the...
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