Cancer

Reports from T.L. Ross and colleagues advance knowledge in cancer

Published in Oncology Business Week, February 22nd, 2009

"The folate receptor (FR) is highly expressed on most epithelia] cancer cells, while normal cells show only restricted expression of FR. As a result, the FR is an ideal target for receptor-based molecular imaging and therapy of cancer and has become a promising target in oncology," scientists writing in the journal Bioconjugate Chemistry report.

"To date, several folate-based chemotherapeutics and imaging probes such as radiopharmaceuticals for single photon emission computed tomography (SPECT) have been developed. However, an F-18-labeled folic acid derivative suitable for positron emission tomography (PET) imaging that can be routinely applied is still lacking....

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Source: Oncology Business Week (2009-02-22)

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