Necrosis
Studies from I. Buck et al add new findings in the area of necrosis
Published in Oncology Business Week, May 3rd, 2009
"The hematopoietic transcription factor GATA-1 regulates the expression of several genes associated with differentiation of erythroid cells. We show here the inhibitory effect of tumor necrosis factor alpha (TNF alpha), a proinflammatory cytokine, on hemoglobinization and erythroid transcription factor GATA-1 expression in erythroleukemia (HEL) as well as in chronic myelogenous leukemia (K562) cells, which were induced to differentiate towards the erythroid lineage after aclacinomycin (Acla), doxorubicin (Dox) or heroin (HM) treatment," researchers in Luxembourg report.
"As a result, we observed i) a decreased expression of Friend of GATA-1 (FOG-1), an essential...
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