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Non-Small Cell Lung Cancer

Study data from Chung-Shan Medical University, Medical Department provide new insights into non-small cell lung cancer

Published in Oncology Business Week, May 3rd, 2009

"The association of aryl hydrocarbon receptor (AhR) overexpression with cytochrome P450 1B1 (CYP1B1) expression is commonly detected in non-small cell lung cancer (NSCLC). In vitro and animal studies have shown an interaction between AhR and p53, or the epidermal growth factor receptor (EGFR)," scientists writing in the journal Anticancer Research report.

"The clinical importance of AhR or CYP1B1 overexpression, however, as well as the relationship between AhR and p53 or EGFR in lung carcinomas, remains unclear. Immunohistochemistry for AhR, CYP1B1, EGFR and/or p53 expression was performed on two tissue microarrays containing 152 NSCLC specimens. High levels of...

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