Melanoma

New findings from J.M. Taube and co-authors describe advances in melanoma

Published in Oncology Business Week, May 24th, 2009

According to recent research published in the American Journal of Surgical Pathology, "Mutational activation of the BRAF oncogene is the most common genetic alteration in cutaneous melanoma. Potentially, BRAF mutation analysis of sentinel lymph node (SLN) biopsies could enhance the detection of micrometastases and improve the accuracy of nodal staging for patients with melanoma."

"Nodal nevi are small aggregates of benign nevus cells that are commonly encountered in the SLNs of patients with melanoma. The status of the BRAF gene in nodal nevi is not known, but this unresolved issue is of critical importance to any future detection strategies that use genetic...

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Source: Oncology Business Week (2009-05-24)

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