Published in Oncology Business Week, May 31st, 2009
"The antiproliferative activity of the SMART agents against melanoma and prostate cancer cells was improved from mc M to low nM range compared with the ATCAA series. The structure-activity relationship was discussed from modifications of ''A'', ''B'', and ''C'' rings and the linker," wrote Y. Lu and colleagues, University of Tennessee.
The researchers concluded: "Preliminary mechanism of action...
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