Leukemia

New research on leukemia from S.K. Arepalli and co-authors summarized

Published in Oncology Business Week, July 26th, 2009

"Bioassay directed fractionation and purification led to the successful isolation of a furano sesquiterpene, Methyl 5-[(1E,5E)-2,6-Dimethyl octa-1,5,7-trienyl] furan-3-carboxylate (MDTFC), a bioactive component from a soft coral, Sinularia kavarittiensis. Its structure was determined by analyzing H-1, C-13 NMR and FAB-MS," scientists in Hyderabad, India report.

"The results show that MDTFC could efficiently and selectively inhibit the proliferation of several human cancer cell lines. Among all the cell lines, THP-1 was found to be most sensitive (IC50 29.59 mc M), whereas the peripheral blood mononuclear cells were least effected (IC50 464.16 mc M). The molecular...

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Source: Oncology Business Week (2009-07-26)

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