Life Sciences

New life sciences study findings have been reported from C.H. Yoon et al

Published in Oncology Business Week, July 26th, 2009

According to a study from South Korea, "Type I IFN-induced expression of dsRNA-activated protein kinase (PKR) during viral infection is a well-established antiviral mechanism. However, little is known about the expression of PKR in the context of p53 and about PKR involvement in p53-mediated tumor suppression."

"Here, we report that PKR is a p53 target gene and plays an important role in the tumor-suppressor function of p53. Activation of p53 by genotoxic stress induces a significant level of PKR expression by acting on the newly identified cis-acting element ( ISRE), which is separated from the IFN-stimulated responsive element on the PKR promoter, resulting in...

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Source: Oncology Business Week (2009-07-26)

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