Published in Oncology Business Week, July 26th, 2009
"Here, we report that PKR is a p53 target gene and plays an important role in the tumor-suppressor function of p53. Activation of p53 by genotoxic stress induces a significant level of PKR expression by acting on the newly identified cis-acting element ( ISRE), which is separated from the IFN-stimulated responsive element on the PKR promoter, resulting in...
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