Published in Oncology Business Week, August 30th, 2009
"To define the genetic network regulated by RARs in breast cancer, we identified RAR genomic targets using chromatin immunoprecipitation and expression analysis. We found that RAR binding throughout the genome is highly coincident with estrogen receptor alpha (ER alpha) binding, resulting in a widespread crosstalk of RA and estrogen signaling to antagonistically regulate breast...
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