Enzyme Research

New enzyme research study findings have been published by scientists at University of Nijmegen, Nijmegen Center for Molecular Life Science

Published in Oncology Business Week, August 30th, 2009

Fresh data on enzyme research are presented in the report 'The ubiquitin ligase Triad1 inhibits myelopoiesis through UbcH7 and Ubc13 interacting domains.' According to recent research from Nijmegen, Netherlands, "Ubiquitination plays a major role in many aspects of hematopoiesis. Alterations in ubiquitination have been implicated in hematological cancer."

"The ubiquitin ligase Triad1 controls the proliferation of myeloid cells. Here, we show that two RING (really interesting new gene) domains in Triad1 differentially bind ubiquitin-conjugating enzymes, UbcH7 and Ubc13. UbcH7 and Ubc13 are known to catalyze the formation of different poly-ubiquitin chains. These chains...

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Source: Oncology Business Week (2009-08-30)

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