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Journal of the National Cancer Institute

DC-SCRIPT found to have prognostic value in breast cancer

Published in Oncology Business Week, January 3rd, 2010

DC-SCRIPT, or dendritic cell-specific transcript, is a key regulator of nuclear receptor activity that may have prognostic value in breast cancer, according to a new study published online December 14 in the Journal of the National Cancer Institute.

In this study, a team led by Gosse J. Adema, Ph.D., of the Department of Tumor Immunology, at the Radboud University Nijmegen Medical Centre, the Netherlands, and colleagues assessed the role of DC-SCRIPT as a co-regulator of nuclear receptors, including estrogen receptor (ER), progesterone receptor (PR)-B, peroxisome proliferator-activated receptor gamma, and retinoic acid receptor alpha. Prognostic value was assessed in...

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