Imaging Agents

Studies from Y. Chen et al add new findings in the area of imaging agents

Published in Oncology Business Week, February 14th, 2010

According to recent research from the United States, "We synthesized YC-27 3 to provide a fluorescent imaging agent for the prostate-specific membrane antigen (PSMA), a marker for hormone-independent prostate cancer and tumor neovasculature, with suitable pharmacokinetics for use in vivo."

"Immediate precursor trifluoroacetate salt of 2-(3-[5-[7-(5-amino-1-carboxy-pentylcarbamoyl)-heptanoylamino]-1-carboxy-pentyl)-ureido)-pentanedioic acid 2 was conjugated with a commercially available near-infrared light-emitting dye (IRDye 800CW) to provide 3 in 72% yield. YC-27 3 demonstrated a PSMA inhibitory activity of 0.37 nM and was capable of generating target-to-nontarget...

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Source: Oncology Business Week (2010-02-14)

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