Metabolism
Recent findings in metabolism described by researchers from University of Toronto, Center for Addiction and Mental Health
Published in Oncology Business Week, March 21st, 2010
A new study, 'Utility and relationships of biomarkers of smoking in African-American light smokers,' is now available. "Although expired carbon monoxide (CO) and plasma cotinine (COT) have been validated as biomarkers of self-reported cigarettes per day (CPD) in heavy smoking Caucasians, their utility in light smokers is unknown. Further, variability in CYP2A6, the enzyme that mediates formation of COT from nicotine and its metabolism to trans-3'-hydroxycotinine (3HC), may limit the usefulness of COT," investigators in Canada report.
"We assessed whether CO and COT are correlated with CPD in African-American light smokers (<or=10 CPD, n=700), a population with known...
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