Xenotransplantion
Findings from St. Jude Children's Research Hospital, Department of Biostatistics advance knowledge in xenotransplantion
Published in Oncology Business Week, April 4th, 2010
New research, 'Assessing cytotoxic treatment effects in preclinical tumor xenograft models,' is the subject of a report. According to recent research published in the Journal of Biopharmaceutical Statistics, "In preclinical solid tumor xenograft experiments, tumor response to cytotoxic agents is often assessed by tumor cell kill. Log10 cell kill (LCK) is commonly used to quantify the tumor cell kill in such experiments."
"For comparisons of antitumor activity between tumor lines, the LCK values are converted to an arbitrary rating; for example, the treatment effect is considered significant if the LCK >0.7 (Corbett et al., 2003). The drawback of using such a...
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