Life Sciences
New life sciences study results from Children's Cancer Institute described
Published in Oncology Business Week, April 4th, 2010
Data detailed in 'Microtubules and resistance to tubulin-binding agents' have been presented. "Microtubules are dynamic structures composed of alpha-beta-tubulin heterodimers that are essential in cell division and are important targets for cancer drugs. Mutations in beta-tubulin that affect microtubule polymer mass and/or drug binding are associated with resistance to tubulin-binding agents such as paclitaxel," scientists in Randwick, Australia report.
"The aberrant expression of specific beta-tubulin isotypes, in particular betaIII-tubulin, or of microtubule-regulating proteins is important clinically in tumor aggressiveness and resistance to chemotherapy. In...
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