Published in Pain and Central Nervous System Week, March 15th, 1999
J.C. Eisenach from Wake Forest University, North Carolina, evaluated muscarinic-mediated drugs for their pain relief potential ("Muscarinic-Mediated Analgesia," Life Sciences, January 8, 1999;64(6-7):549-554).
"Systemic administration of cholinesterase inhibitors which cross the blood brain barrier have long been known to produce analgesia and enhance analgesia from opiates," wrote Eisenach. "A major site of analgesic action of cholinergic agents is the spinal cord."
The researcher noted that muscarinic receptors are concentrated in...
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