Neurology

Gene-Trapping Method Powers Discovery of New Brain-Wiring Signals

Published in Pain and Central Nervous System Week, March 31st, 2001

Researchers have developed a powerful screening method to identify genes that produce proteins that guide the wiring of the trillions of connections in the mammalian brain.

The technique enables scientists to identify new genes and to determine which genes are responsible for defects in brain wiring that are observed during development. The scientists believe that this technique is likely to accelerate the discovery of new molecules involved in axon guidance.

Neurons wire themselves into networks by extending cable-like axons that grow toward specific targets in the nervous system. An axon's path toward a target neuron is steered by growth cones...

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Source: Pain and Central Nervous System Week (2001-03-31)

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