Alzheimer Disease
22R-hydroxycholesterol protects from beta-amyloid peptide's cytotoxicity
Published in Pain and Central Nervous System Week, February 10th, 2003
According to recent research from the United States, "22R-hydroxycholesterol, a steroid intermediate in the pathway of pregnenolone formation from cholesterol, was found at lower levels in Alzheimer disease (AD) hippocampus and frontal cortex tissue specimens compared to age matched controls. Beta-amyloid (Abeta) peptide has been shown to be neurotoxic and its presence in brain has been linked to AD pathology. 22R-hydroxycholesterol was found to protect, in a dose dependent manner, against Abeta-induced rat sympathetic nerve pheochromocytoma (PC12) and differentiated human Ntera2/D1 teratocarcinoma (NT2N) neuron cell death.
"Other steroids tested were either inactive...
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