Pain & Central Nervous System Week
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Axonal Degeneration
Blockers of sodium and calcium entry protect axons from nitric oxide
March 31st, 2003
Blockers of sodium and calcium entry protect axons from nitric oxide. According to a study from England, "Axonal degeneration can be an important cause of permanent disability in neurological disorders in which inflammation is prominent, including multiple sclerosis and Guillain-Barre syndrome. The mechanisms responsible for the degeneration remain unclear, but it is likely that axons succumb to factors produced at the site of inflammation, such as nitric oxide (NO). "We previously have shown that axons exposed to NO in vivo can undergo degeneration, especially if the axons are electrically active during NO exposure. The axons may degenerate...
Source: Pain & Central Nervous System Week (2003-03-31)
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