Pain & Central Nervous System Week
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Alzheimer Disease
Columbia researchers identify possible new culprit in plaque formation
March 31st, 2003
A new study from Columbia University College of Physicians and Surgeons (P&S) and Stanford University suggests that the malfunctioning of brain cells called astrocytes may be behind the accumulation of amyloid protein in the brains of patients with Alzheimer disease. Alzheimer disease, most researchers believe, is caused when small peptides called beta-amyloid accumulate in the brain. Everyone makes these peptides at all times during their life, but in people with Alzheimer, either too much is made or too little is degraded or both. The resulting excess of peptides aggregate together in plaques. Beta-amyloid plaques then lead to death of neurons and dementia. ...
Source: Pain & Central Nervous System Week (2003-03-31)
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