Pain & Central Nervous System Week
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Gliomal Cell Surface
Stripping proteoglycans of sulfation leads to adhesional and migrational changes
March 31st, 2003
Stripping proteoglycans of sulfation leads to adhesional and migrational changes. According to recent research from Brazil, "Proteoglycans are considered to be important molecule in cell-microenvironment interactions. They are overexpressed in neoplastic cells modifying their growth and migration in hosts. In this work we verified that undersulfation of proteoglycans and other sulfated molecules, induced by sodium chlorate treatment, inhibited C6 glioma cells proliferation in a dose dependent way. "This effect was restored by the addition of exogenous heparin. We could not detect significant cell mortality in our culture condition. The treatment...
Source: Pain & Central Nervous System Week (2003-03-31)
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