Pain & Central Nervous System Week
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Leptin Studies
Depressed women exhibit higher leptin concentrations
March 31st, 2003
A sexual diergism of baseline plasma leptin and leptin suppression by arginine vasopressin was found in patients with depression. According to a study from the United States, "Leptin inhibits appetite by activating several neuroendocrine systems, including the hypothalamo-pituitary-adrenal cortical (HPA) axis. In turn, chronically elevated glucocorticoids increase circulating leptin. HPA axis hyperactivity occurs in 30-50% of patients with major depression, but the few prior reports of leptin measurements in this illness have shown inconsistent results." "We, therefore, measured plasma leptin in 12 female and 8 male unipolar major depressives and...
Source: Pain & Central Nervous System Week (2003-03-31)
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