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Malaria Pathogenesis
Perforin-dependent cytotoxic T cells mediate cerebral malaria development
March 31st, 2003
Perforin-dependent cytotoxic T cells play a key role in the pathogenesis of cerebral malaria. "Experimental cerebral malaria (ECM) resulting from Plasmodium berghei ANKA infection involves T lymphocytes," researchers in France explained. "However, the mechanisms of T cell-mediated pathogenesis remain unknown." J. Nitcheu and coauthors at the University of Paris found that, "in contrast to ECM-susceptible C57BL6 mice, perforin-deficient (PFP-KO) mice were resistant to ECM in the absence of brain lesions, whereas cytoadherence of parasitized erythrocytes and massive accumulation of activated/effector CD8 lymphocytes were observed in both groups...
Source: Pain & Central Nervous System Week (2003-03-31)
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