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HIV/AIDS Dementia
Novel mechanism identified for neural cell infection
March 31st, 2003
A novel mechanism has been identified for HIV infection of neural cells. In a recent study from Spain, researchers used human neuroblastoma (NB) cell lines "to study the mechanism by which HIV-1 infects neurons". "NB (SK-N-SH and SK-N-MC) were found to be susceptible to productive infection by X4- or R5 HIV-1, as detected by viral load and Ag-p24," according to S. A. Losada and colleagues at Hospital General Universitario Gregorio Maranon "To identify the putative receptor, we tested the cell surface expression of previously described receptors such as CD4, nucleolin, galactosylceramide, and CCR1, CCR5, and CXCR4 by cytometry and...
Source: Pain & Central Nervous System Week (2003-03-31)
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