Pain & Central Nervous System Week
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Neuroscience
Alzheimer disease may have a link to cerebral angiogenesis
March 31st, 2003
Alzheimer disease may have a link to cerebral angiogenesis. "Despite enormous investigative efforts, the pathological basis for Alzheimer's disease remains unclear. Suggested mechanisms for the disorder include cerebral hypoperfusion, inflammation, gene polymorphisms, and molecular lesions in the brain. In this hypothesis, we argue that the vascular endothelial cell has a central role in the progressive destruction of cortical neurons in Alzheimer's disease," researchers in the United States report. "In Alzheimer's disease, the brain endothelium secretes the precursor substrate for the beta-amyloid plaque and a neurotoxic peptide that selectively...
Source: Pain & Central Nervous System Week (2003-03-31)
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