Pain & Central Nervous System Week
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Neurodegeneration
Adenovirus-based GDNF gene transfer stops motoneuron loss
March 31st, 2003
Adenovirus-based GDNF gene transfer stops motoneuron loss. "We examined neuroprotective effects of an adenoviral vector encoding glial cell line-derived neurotrophic factor (AxCAhGDNF) on the lesioned adult rat motoneurons in the nucleus ambiguus," according to researchers in Japan. "After vagal nerve avulsion, AxCAhGDNF, AxCALacZ (adenovirus encoding beta-galactosidase gene) or phosphate buffered saline was inoculated into the jugular foramen. Four days after the avulsion and treatment with AxCALacZ, the animals expressed beta-galactosidase activity in the lesioned motoneurons in the nucleus ambiguus," remarked K. Saito and coauthors, Keio...
Source: Pain & Central Nervous System Week (2003-03-31)
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