Pain & Central Nervous System Week
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Sensory Neuropathy
Monoclonal IgM is bound to a trisulfated heparin disaccharide
March 31st, 2003
Monoclonal IgM is found to be bound to a trisulfated heparin disaccharide. Recent research from the United States "studied clinical and serological features of 5 patients with polyneuropathy and serum immunoglobulin M (IgM) binding to the trisulfated disaccharide IdoA2S-GlcNS-6S (TS-HDS), the most abundant disaccharide component of heparin oligosaccharides. The patients all had painful, predominantly sensory polyneuropathies. Sensory loss was distal and panmodal. "Electrophysiological and pathological studies were consistent with axonal loss, especially of unmyelinated axons. Immunohistochemistry showed IgM and kappa light chains deposited around...
Source: Pain & Central Nervous System Week (2003-03-31)
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