Pain & Central Nervous System Week
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Stem Cell Research
Immortalized neural stem cells downregulate MHC molecules after differentiation
March 31st, 2003
Immortalized neural stem cells downregulate major histocompatibility complex (MHC) molecules after differentiation. MHC antigen expression "on the surface of cells is intimately linked to in vivo graft survival," researchers in England explained. According to M. Modo and colleagues at the Neuroimaging Research Group, previous studies have shown that "the conditionally immortalized temperature-sensitive Maudsley hippocampal clone 36 (MHP36) neural stem cells show good long-term graft survival and do not elicit an acute immunological response following transplantation." Modo and coworkers examined MHC molecule expression by these...
Source: Pain & Central Nervous System Week (2003-03-31)
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