Pain & Central Nervous System Week
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Alzheimer Disease
Autopsy exposes adverse effects of vaccine
March 31st, 2003
The only clinical trial for an experimental Alzheimer disease (AD) vaccine was halted last year when 15 of the trial participants developed severe brain inflammation. Now James Nicoll and colleagues have presented the first analysis of the vaccine's effects on the human brain. In the U.S. alone, AD affects nearly 4 million people, and the number is expected to triple in the next 30 years. The brain of an AD patient is characterized by tangled bundles of nerve fibers and amyloid "plaques" - clusters of a sticky protein called amyloid-beta. In mice, a vaccine directed against the amyloid-beta peptide clears the plaques and alleviates the memory loss associated with AD....
Source: Pain & Central Nervous System Week (2003-03-31)
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