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Pain and Central Nervous System Week

Susan Hasty, Publisher

Table of Contents . . . July 28th, 2003

Non-Subscriber - Summaries Only

Related Areas: Other Issues in Pain and Central Nervous System Week | Other Publications

Epilepsy - Brain imaging predicts language impairment before epilepsy surgery

Multiple Sclerosis - Study documents risk of developing MS 10 years after having optic neuritis

Neuroscience - Src and CD44 are potential targets for the treatment of peripheral nerve tumors

Neurotoxin - Brain neuronal degeneration occurs after single Ecstasy exposure

Stem Cell Research - Transplanted human neural stem cells replace lost brain cells in rats

Stroke Rehabilitation - Drug improves the sense of touch

Acute Ischemic Stroke - UC San Diego collaborates on stroke clinical trial

Age-related Memory Impairments - Compounds reverse age-related learning deficits in mice

Alcoholism - Alcohol ads stimulate stronger brain responses in drinking than teetotaling teens

Alzheimer Disease - Beta amyloid resorption and degradation appears to occur only in astrocytes

Alzheimer Disease - Polymorphisms in the IL-10 promoter region do not appear to be linked

Alzheimer Disease - Promising findings reported from Alzhemed phase II study

Alzheimer Disease - Study: Aricept therapy associated with delayed nursing home placement

Alzheimer Histology - Formic acid pretreatment may overenhance amyloid plaque, heat does not

Amyotrophic Lateral Sclerosis - CytRx licenses RNAi technology

Amyotrophic Lateral Sclerosis - Protein deficiency link found

Aneurysm - Advanced imaging techniques key for optimal treatment decisions

Ankylosing Spondylitis - First biologic recommended by FDA panel for inflammatory disease

Attention Deficit Hyperactivity Disorder - Focalin LA pivotal clinical trial initiated in adults with ADD/ADHD

Attention Deficit Hyperactivity Disorder - Once-daily Adderall XR provides all-day symptom control for children

Brain Disease - Niemann-Pick and Alzheimer disease have tangled neurons with high cholesterol

Brain Tumors - Cladribine and 2-chloro-adenosine induce apoptosis of human astrocytoma cells

Brain Tumors - Loss of GFAP expression in astrocytomas does not contribute to tumor development

Chalazion - Chalazion may have a more diffuse clinical presentation

Chronic Pain - Pivotal phase III study of Oxytrex launched

Collaborations - Orthopedic rehabilitation program expands

Collaborations - Pharmaceutical firm, Duke University announce drug discovery alliance

Conjunctival Tumor - Conjunctival nevus of presumed late onset is resected

Degenerative Disc Disease - FDA approves start of clinical study on Actipore PLFx

Dementia - Higher education or larger brain size may protect against dementia later in life

Dementia - Lewy bodies are frequently found in familial Alzheimer disease

Depression - Pittsburgh researchers single out genes for major depression

Down Syndrome - Treadmill training helps kids walk earlier

Drug Use - Brazilian truck driver drug use is at 6%, according to immunoassay on urine

Epilepsy - Battling the brainstorm

Epilepsy - CE Mark approval granted to market VNS therapy system

Epilepsy - UCLA leads $30 million NIH study

Ethics - Patients who request and receive physician-assisted death have high burden of physical pain

Fever - 'Tunnel' allows external continuous measurement of brain temperature

Finance - Alzheimer disease device company closes $40M private placement

Gulf War Syndrome - Quick return to normal routine could help avoid symptoms

HIV/AIDS Dementia - Viral Tat regulates MCP-1 transcription through TGFbeta-1 pathway

Hypertension - U. Iowa study adds to understanding of salt-taste

Infectious Disease Therapy - Hemodialysis patients may be at risk of cefepime-induced neurotoxicity

Inflammatory Bowel Disease - The mu opioid receptor has strong anti-inflammatory control in colitis models

Mental Disease - Frontotemporal dementia neurons have positive p62 and ubiquitin inclusions

Migraine - Headaches devastating to children's quality of life

Migraine Headache - Increased blood flow to rostral brainstem, neuronal hyperexitability involved

Migraine Trends - Drug market to double from $2.86 billion in 2002 to $5.6 billion in 2012

Multiple Sclerosis - Autoimmune optic neuritis may target myelin oligodendrocyte glycoprotein

Multiple Sclerosis - Avonex prefilled syringe approved in Europe

Multiple Sclerosis - Glatiramer acetate, similar to myelin basic protein, is effective MS therapy

Multiple Sclerosis - New blood test may help with diagnosis

Multiple Sclerosis - Patients have higher amylolytic activity in their IgM and IgG antibodies

Nerve Sheath Tumors - Schwann cell is the source of heterologous elements in nerve sheath tumors

Neurilemmoma - Neurilemmoma attached to the tendon of the flexor digitorum longus muscle

Neurology - "Stroke Management Markets and Strategies" published

Neuroscience - Antisense suppression of the Shaker-like KvI.I gene halts amphetamine's effects

Neuroscience - PDGF signal regulation might be suitable for treating stroke patients

Nicotine Addiction - Smokers who first lit up as teens more likely to smoke after stroke

Obstructive Sleep Apnea - Sleep disorders linked to faulty brain chemistry, study finds

Ocular Damage - Lens epithelial cell survival is enhanced by LEDGF activation of PKC gamma

Ophthalmology - Disarming 'glial' cells may solve retinal transplantation barrier

Ophthalmology - Scientists figure out bizarre visual condition

Pain Control - Association produces brochure to help patients manage pain

Pancreatic Pain - Pain produced by chronic pancreatitis could be through neuroimmune interaction

Parkinson Disease - More postmortem cerebrovascular lesions appear unrelated to cognitive impairment

Parkinson Disease - Nicotinamide N-methyltransferase is high in cerebellum; may be pathogenic

Prenatal Health - Low cholesterol may damage fetal development

Rheumatology - Novel orally active MMP inhibitors could knock down osteoarthritis

Rheumatology - TRAIL gene transfer reduces inflammatory tissues in arthritis models

Seizures - ANDA approval granted for valproate sodium injection

Stress - Chill out: Anger can give you a headache

Stroke - Early intervention with Atacand improves outcome

Stroke - Growth factor promotes new blood routes in rat brain

Stroke - Interferon regulatory factor-1 may be linked to cerebral ischemia and stroke

Stroke - Primary care doctors make a difference in deaths

Stroke - Stem-like cells from peripheral blood restore function in rats

Stroke - Study compares Amplatzer PFO Occluder and standard drug treatment

TMJ Disease - IL-6 in synovium may be related to the grade of joint effusion in jaw

Traumatic Brain Injury - U.S. enrollment initiated in phase III study of dexanabinol

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