Published in Pain and Central Nervous System Week, July 28th, 2003
"Niemann-Pick type C disease is an inherited neurovisceral storage disorder with intracellular accumulation of cholesterol. In affected brains, many ballooned neurons are seen. Considerable nerve cell loss of unknown pathogenesis leads to neurological deterioration and dementia. Chemical examination of brains has failed to demonstrate increased levels of cholesterol," investigators in Germany report.
"Using filipin fluorometry of neuronal cells in tissue slices, we found massive accumulation of...
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