Brain Disease

Niemann-Pick and Alzheimer disease have tangled neurons with high cholesterol

Published in Pain and Central Nervous System Week, July 28th, 2003

In Niemann-Pick type C disease and in Alzheimer disease, tangled neurons are associated with cholesterol accumulation, thus these phenomena may be related.

"Niemann-Pick type C disease is an inherited neurovisceral storage disorder with intracellular accumulation of cholesterol. In affected brains, many ballooned neurons are seen. Considerable nerve cell loss of unknown pathogenesis leads to neurological deterioration and dementia. Chemical examination of brains has failed to demonstrate increased levels of cholesterol," investigators in Germany report.

"Using filipin fluorometry of neuronal cells in tissue slices, we found massive accumulation of...

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Source: Pain and Central Nervous System Week (2003-07-28)

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