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Pain and Central Nervous System Week

Susan Hasty, Publisher

Table of Contents . . . October 27th, 2003

Non-Subscriber - Summaries Only

Related Areas: Other Issues in Pain and Central Nervous System Week | Other Publications

Prion Diseases - RNA may boost rogue prions

Spinal Cord Injury - Thoughts translate to actions

Alzheimer Disease - Animal research points to new direction for AD therapy

Neuroscience - Role of dopamine D4 receptor gene mutations in ADHD clarified

Stroke Rehabilitation - Imagining movement of affected limbs aids stroke recovery

Addiction Medicine - Researchers receive $4.9 million grant to continue study of prenatal exposure

Adverse Drug Effects - Apoptosis precedes necrosis in acetaminophen-induced liver injury

Alzheimer Disease - Breakthrough cancer drug offers hope for Alzheimer patients

Alzheimer Disease - Consortium formed to advance state-of-the-art neurological research

Alzheimer Disease - Early, accurate diagnosis of AD possible with urine sample

Alzheimer Disease - Exercise and caregiver training can improve mood, physical health for patients

Alzheimer Disease - Insulin and IGF-1 may have therapeutic roles in Alzheimer disease

Alzheimer Disease - Physicist devises way to observe protein folding

Amyotrophic Lateral Sclerosis - Oxidative stress involved in neurodegeneration of ALS

Anal Fissures - Enrollment in Cellegesic phase III trial passes two-thirds mark

Antineuronal Antibodies - Anti-Ma2 antibody may occur in breast cancer expressing Ma1, Ma2, and Ma3

Antipneumococcal Activity - LPS binding protein also binds non-lipid sections of pneumococcal cell wall

Arteriovenous Fistulae - Treatment and outcome of spinal dural arteriovenous fistulas are examined

Autoimmune Disease - Protein microarrays guide DNA vaccine treatment of autoimmune disease

Behcet Disease - Finding genetic, environmental factors in Behcet disease may help predict risk

Biogenic Amine Transporters - Lymphocytes transport neurotransmitters; transporter substrates alter immunity

Brain Cancer - Study of brain tumors points to resection over biopsy as one key to survival

Brain Injury - Damage to the frontal lobes can affect a person's ability to "stay on the job"

Brain Tumors - Combination of 2D PAGE, MALDI-TOF-MS successful as global screening tool for CSF

Brain Tumors - New 3-D tortuosity metric seems to detect several kinds of abnormalities

Cancer - Sleep may fight cancer progression

Central Nervous System - FDA puts phase III trial of antianxiety product on hold

Central Nervous System - Myelin-associated inhibitors of axonal regeneration reviewed

Cerebral Aneurysms - NIH grant to be used for development of a collagen-based coil

Cerebral Malaria - Role of TNF-alpha in cerebral malaria pathogenesis reviewed

Cognitive Function - Biological basis for creativity linked to mental illness

Complementary and Alternative Medicine - St. John's wort affects neuroendocrine responses to 5-T-2A agonist

Degenerative Brain Diseases - Squid research unlocking mysteries of the brain

Depression - Regulatory plan reiterated after pre-PMA-S meeting with FDA

Dermatology - FDA approves generic lidocaine/prilocaine cream

Developmental Biology - Study describes how genes orchestrate facial expressions

Emotion - Pathways of emotion - from cortex to peripheral organs - described

Emotion - Rejection really hurts, psychologists find

Endothelium - Flk-1 and Flt-1 receptors take a time-dependent course in rat brain expression

Epilepsy - Company receives tentative approval for generic Topiramate tablets

Epilepsy - Magnetic fields guide brain surgery

Fetal Medicine - Toxemia, specific language impairment may be caused by low essential fatty acids

Fragile X Syndrome - Neurodegeneration caused by the fragile X premutation rCGG repeats

Gene Targeting - Lentiviral vectors have advantages for brain cell transfection

Generalized Anxiety Disorder - Lexapro gets approvable letter from FDA

Genetic Disorders - Gene locus for novel form of Joubert syndrome identified

Genetic Disorders - Hereditary sensory neuropathy locus found on chromosome 3p22-p24

Genetic Disorders - Loci with possible effects on age of Huntington disease onset identified

Geriatrics - Gender and apolipoprotein E are predictive factors for Alzheimer disease

Glioma - ERBB receptor tyrosine kinases, cellular radiation responses reviewed

HIV/AIDS Neurotoxicity - Schwann cell chemokine receptors mediate HIV gp120 toxicity to sensory neurons

HIV/AIDS Vaccine - Adenoviral vector HIV vaccine stimulates enhanced mucosal IgA response

Headache and Migraine -  ATP1A2 mutations linked to familial migraine with aura

Hearing Disorders - Genes that regulate hearing link humans and fruit flies in new way

Hematology - Brain morphogenetic gene Otx1 plays unexpected role in hematopoiesis

Hypoxia - Agreement signed for access to eTag assay system

Immunology - Morphine suppresses p53-mediated lymphocyte apoptosis

Inflammatory Myopathy - S100 proteins MRP8, MRP14 are secreted by macrophages, cause myocyte apoptosis

Injury Prevention - Paper analyzes concussions in professional football

Innate Immunity Lectin - Transfusion of recombinant mannan-binding lectin may help treat many diseases

Ischemic Stroke - Herpes simplex virus-based gene delivery generates neuroprotective effects

Magnetic Resonance Imaging - The formation of a cerebral mycotic aneurysm was captured by serial imaging

Market Analysis - Drug market for multiple sclerosis will be driven by growth of patient population

Meningitis - Even in WNV epizootic areas, enteroviruses still main cause of meningitis

Mergers and Acquisitions - Fisher's SPS is acquired by Medmark

Migraine - FDA approves new Zomig (zolmitriptan) nasal spray formulation

Migraine Headache - Sumatriptan succinate tablets effective in treating menstrual migraines

Multiple Sclerosis - Detection of antibodies could identify patients who do not respond well to interferon beta

Multiple Sclerosis - Licensing rights to Fampridine-SR expanded

Multiple Sclerosis - MS has four subtypes, histologically; demyelination may be from different causes

Multiple Sclerosis - Reduction of MS lesions by interferon-beta may involve MMPs, adhesion molecules

Multiple Sclerosis - Research: Copaxone slows accumulation of disability and reduces relapse rate

Narcolepsy - Sodium oxybate has gone from club drug to orphan drug to treat cataplexy

Nasu-Hakola Disease - Osteoclasts depend on TREM-2 to fully differentiate; lack of TREM-2 produces NHD

Nausea - Schering-Plough inks licensing agreement for palonosetron

Neurologic Disease Genetics - Multiple sclerosis, even after whole genome screens, has had few genetic hits

Neurology - 14-3-3 Proteins in the nervous system reviewed

Neurology - BACH function elucidated

Neurology - Disease mechanisms in inherited neuropathies reviewed

Neurology - Distal motor and residual latency are markers of anti-MAG polyneuropathy

Neurology - Osmotic swelling induces p75 neurotrophin receptor expression

Neurology - Structure of JNK3 in complex with small molecule inhibitors reported

Neuropathic Pain - Positive results reported in phase II trial with cannabinoid compound

Neuroprotective Drugs - Parkinson disease drug pramipexole functions by speeding dopamine uptake

Neuroscience - MARS alleviates neurological progression in liver disease-related coma

Neuroscience - MRI of the spinal-cord helps to confirm multiple sclerosis diagnoses

Neuroscience - Parturition activates proteins that initiate maternal behavior

Neuroscience - Zic2 plays key role in binocular vision

Neurotoxin - Toxic phospholipase from venom of Vipera ammodytes meridionalis reported

Obesity Surgery - Surgical obesity treatment reduces risk of musculoskeletal pain

Obstetrics - Alloimmune thrombocytopenia can be detected and even treated in utero

Pain Medicine - Glial cell-derived neurotrophic factor genes relieve neurotrophic pain

Pain Medicine - Natural chemical curbs neuropathic pain

Pain Therapy - Progress report provided on the development of ENT-103

Parkinson Disease - Animal models offer insight into role of alpha-synuclein in Parkinson disease

Pediatrics - Multidisciplinary approaches benefit children with neuromuscular disorders

Personnel - Contract-research organization announces executive appointments

Postoperative Pain - FDA accepted DepoMorphine NDA for filing

Prenatal Testing - Company announces milestone in development of noninvasive Down syndrome test

RNA Research - BC1 RNA stimulates exploration in mice

Retinal Ischemia - Pentoxifylline may have protective effect in retinal ischemia/reperfusion injury

Retinitis Pigmentosa - The genetics of blindness disease uncovered

Rheumatoid Arthritis - Beneficial effects of antibodies to interferon-gamma presented

Spasticity - FDA grants approval for tizanidine hydrochloride

Stem-Cell Research - Positional identity gene expression codes not preserved in cultured neural stem cells

Stem-Cell Research - SDNSF helps maintain lifelong neurogenesis

Stress - Chronic stress increases glucocorticoids, catecholamines

Stroke - Researchers uncover the brain's stroke protection system

Stroke - Vision restoration therapy to be launched in U.S. and Europe

Toxicology - Acetaminophen restriction curbs new emergency liver transplants in the U.K.

West Nile Virus - Season saw screening weaknesses, a rash of polio-like cases

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