Susan Hasty, Publisher
Table of Contents . . . October 27th, 2003
Non-Subscriber - Summaries OnlyRelated Areas: Other Issues in Pain and Central Nervous System Week | Other Publications
Prion Diseases - RNA may boost rogue prions
Spinal Cord Injury - Thoughts translate to actions
Alzheimer Disease - Animal research points to new direction for AD therapy
Neuroscience - Role of dopamine D4 receptor gene mutations in ADHD clarified
Stroke Rehabilitation - Imagining movement of affected limbs aids stroke recovery
Addiction Medicine - Researchers receive $4.9 million grant to continue study of prenatal exposure
Adverse Drug Effects - Apoptosis precedes necrosis in acetaminophen-induced liver injury
Alzheimer Disease - Breakthrough cancer drug offers hope for Alzheimer patients
Alzheimer Disease - Consortium formed to advance state-of-the-art neurological research
Alzheimer Disease - Early, accurate diagnosis of AD possible with urine sample
Alzheimer Disease - Exercise and caregiver training can improve mood, physical health for patients
Alzheimer Disease - Insulin and IGF-1 may have therapeutic roles in Alzheimer disease
Alzheimer Disease - Physicist devises way to observe protein folding
Amyotrophic Lateral Sclerosis - Oxidative stress involved in neurodegeneration of ALS
Anal Fissures - Enrollment in Cellegesic phase III trial passes two-thirds mark
Antineuronal Antibodies - Anti-Ma2 antibody may occur in breast cancer expressing Ma1, Ma2, and Ma3
Antipneumococcal Activity - LPS binding protein also binds non-lipid sections of pneumococcal cell wall
Arteriovenous Fistulae - Treatment and outcome of spinal dural arteriovenous fistulas are examined
Autoimmune Disease - Protein microarrays guide DNA vaccine treatment of autoimmune disease
Behcet Disease - Finding genetic, environmental factors in Behcet disease may help predict risk
Biogenic Amine Transporters - Lymphocytes transport neurotransmitters; transporter substrates alter immunity
Brain Cancer - Study of brain tumors points to resection over biopsy as one key to survival
Brain Injury - Damage to the frontal lobes can affect a person's ability to "stay on the job"
Brain Tumors - Combination of 2D PAGE, MALDI-TOF-MS successful as global screening tool for CSF
Brain Tumors - New 3-D tortuosity metric seems to detect several kinds of abnormalities
Cancer - Sleep may fight cancer progression
Central Nervous System - FDA puts phase III trial of antianxiety product on hold
Central Nervous System - Myelin-associated inhibitors of axonal regeneration reviewed
Cerebral Aneurysms - NIH grant to be used for development of a collagen-based coil
Cerebral Malaria - Role of TNF-alpha in cerebral malaria pathogenesis reviewed
Cognitive Function - Biological basis for creativity linked to mental illness
Complementary and Alternative Medicine - St. John's wort affects neuroendocrine responses to 5-T-2A agonist
Degenerative Brain Diseases - Squid research unlocking mysteries of the brain
Depression - Regulatory plan reiterated after pre-PMA-S meeting with FDA
Dermatology - FDA approves generic lidocaine/prilocaine cream
Developmental Biology - Study describes how genes orchestrate facial expressions
Emotion - Pathways of emotion - from cortex to peripheral organs - described
Emotion - Rejection really hurts, psychologists find
Endothelium - Flk-1 and Flt-1 receptors take a time-dependent course in rat brain expression
Epilepsy - Company receives tentative approval for generic Topiramate tablets
Epilepsy - Magnetic fields guide brain surgery
Fetal Medicine - Toxemia, specific language impairment may be caused by low essential fatty acids
Fragile X Syndrome - Neurodegeneration caused by the fragile X premutation rCGG repeats
Gene Targeting - Lentiviral vectors have advantages for brain cell transfection
Generalized Anxiety Disorder - Lexapro gets approvable letter from FDA
Genetic Disorders - Gene locus for novel form of Joubert syndrome identified
Genetic Disorders - Hereditary sensory neuropathy locus found on chromosome 3p22-p24
Genetic Disorders - Loci with possible effects on age of Huntington disease onset identified
Geriatrics - Gender and apolipoprotein E are predictive factors for Alzheimer disease
Glioma - ERBB receptor tyrosine kinases, cellular radiation responses reviewed
HIV/AIDS Neurotoxicity - Schwann cell chemokine receptors mediate HIV gp120 toxicity to sensory neurons
HIV/AIDS Vaccine - Adenoviral vector HIV vaccine stimulates enhanced mucosal IgA response
Headache and Migraine - ATP1A2 mutations linked to familial migraine with aura
Hearing Disorders - Genes that regulate hearing link humans and fruit flies in new way
Hematology - Brain morphogenetic gene Otx1 plays unexpected role in hematopoiesis
Hypoxia - Agreement signed for access to eTag assay system
Immunology - Morphine suppresses p53-mediated lymphocyte apoptosis
Inflammatory Myopathy - S100 proteins MRP8, MRP14 are secreted by macrophages, cause myocyte apoptosis
Injury Prevention - Paper analyzes concussions in professional football
Innate Immunity Lectin - Transfusion of recombinant mannan-binding lectin may help treat many diseases
Ischemic Stroke - Herpes simplex virus-based gene delivery generates neuroprotective effects
Magnetic Resonance Imaging - The formation of a cerebral mycotic aneurysm was captured by serial imaging
Market Analysis - Drug market for multiple sclerosis will be driven by growth of patient population
Meningitis - Even in WNV epizootic areas, enteroviruses still main cause of meningitis
Mergers and Acquisitions - Fisher's SPS is acquired by Medmark
Migraine - FDA approves new Zomig (zolmitriptan) nasal spray formulation
Migraine Headache - Sumatriptan succinate tablets effective in treating menstrual migraines
Multiple Sclerosis - Detection of antibodies could identify patients who do not respond well to interferon beta
Multiple Sclerosis - Licensing rights to Fampridine-SR expanded
Multiple Sclerosis - MS has four subtypes, histologically; demyelination may be from different causes
Multiple Sclerosis - Reduction of MS lesions by interferon-beta may involve MMPs, adhesion molecules
Multiple Sclerosis - Research: Copaxone slows accumulation of disability and reduces relapse rate
Narcolepsy - Sodium oxybate has gone from club drug to orphan drug to treat cataplexy
Nasu-Hakola Disease - Osteoclasts depend on TREM-2 to fully differentiate; lack of TREM-2 produces NHD
Nausea - Schering-Plough inks licensing agreement for palonosetron
Neurologic Disease Genetics - Multiple sclerosis, even after whole genome screens, has had few genetic hits
Neurology - 14-3-3 Proteins in the nervous system reviewed
Neurology - BACH function elucidated
Neurology - Disease mechanisms in inherited neuropathies reviewed
Neurology - Distal motor and residual latency are markers of anti-MAG polyneuropathy
Neurology - Osmotic swelling induces p75 neurotrophin receptor expression
Neurology - Structure of JNK3 in complex with small molecule inhibitors reported
Neuropathic Pain - Positive results reported in phase II trial with cannabinoid compound
Neuroprotective Drugs - Parkinson disease drug pramipexole functions by speeding dopamine uptake
Neuroscience - MARS alleviates neurological progression in liver disease-related coma
Neuroscience - MRI of the spinal-cord helps to confirm multiple sclerosis diagnoses
Neuroscience - Parturition activates proteins that initiate maternal behavior
Neuroscience - Zic2 plays key role in binocular vision
Neurotoxin - Toxic phospholipase from venom of Vipera ammodytes meridionalis reported
Obesity Surgery - Surgical obesity treatment reduces risk of musculoskeletal pain
Obstetrics - Alloimmune thrombocytopenia can be detected and even treated in utero
Pain Medicine - Glial cell-derived neurotrophic factor genes relieve neurotrophic pain
Pain Medicine - Natural chemical curbs neuropathic pain
Pain Therapy - Progress report provided on the development of ENT-103
Parkinson Disease - Animal models offer insight into role of alpha-synuclein in Parkinson disease
Pediatrics - Multidisciplinary approaches benefit children with neuromuscular disorders
Personnel - Contract-research organization announces executive appointments
Postoperative Pain - FDA accepted DepoMorphine NDA for filing
Prenatal Testing - Company announces milestone in development of noninvasive Down syndrome test
RNA Research - BC1 RNA stimulates exploration in mice
Retinal Ischemia - Pentoxifylline may have protective effect in retinal ischemia/reperfusion injury
Retinitis Pigmentosa - The genetics of blindness disease uncovered
Rheumatoid Arthritis - Beneficial effects of antibodies to interferon-gamma presented
Spasticity - FDA grants approval for tizanidine hydrochloride
Stem-Cell Research - Positional identity gene expression codes not preserved in cultured neural stem cells
Stem-Cell Research - SDNSF helps maintain lifelong neurogenesis
Stress - Chronic stress increases glucocorticoids, catecholamines
Stroke - Researchers uncover the brain's stroke protection system
Stroke - Vision restoration therapy to be launched in U.S. and Europe
Toxicology - Acetaminophen restriction curbs new emergency liver transplants in the U.K.
West Nile Virus - Season saw screening weaknesses, a rash of polio-like cases
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