Susan Hasty, Publisher
Table of Contents . . . December 15th, 2003
Non-Subscriber - Summaries OnlyRelated Areas: Other Issues in Pain and Central Nervous System Week | Other Publications
Brain Cancer - Study finds new clues to the origins of brain tumors
Developmental Biology - Fat molecules make bigger brains
Alzheimer Disease - New technique detects earliest signs of cognitive decline in healthy people
Brain Remodeling - Scientists discover how brain draws and re-draws picture of world
Speech Pathology - Brain activity abnormal in children with delayed speech
Stroke Mortality - More sudden deaths after left-sided stroke than after right-sided
Addiction Medicine - MK-801 attenuates cocaine induction of preprodynorphin mRNA levels
Alzheimer Disease - Amyloid plaque-forming beta-secretase BACE1 is controlled by heparan sulfate
Alzheimer Disease - Beta-amyloid released from lipid membrane by methionine oxidation
Alzheimer Disease - Caspase generates protein fragments with Smac/Diablo-like activities
Alzheimer Disease - Dehydroepiandrosterone reduces activity of BACE in stressed NT2 neurons
Alzheimer Disease - Patients learn how to stave off debilitating disease
Alzheimer Disease - Update on pharmacologic treatment of Alzheimer disease released
Alzheimer Disease - X-34 exhibits antioxidant activity in synaptosomal and neuronal systems
Anesthesia - Study explores whether new monitor helps patients recover faster
Anti-Infectives - Long-term linezolid treatment can cause toxic optic neuropathy
Atrial Fibrillation - Warfarin effective for stroke prevention
Attention Deficit/Hyperactivity Disorder - ANDA filed for generic version of Adderall
Autism - Humanoid robot to aid autism diagnosis is goal of new study
Autism - Large-scale study to try and unlock brain's mysteries
Botulism - Potent inhibitors of botulinum neurotoxin type B developed
Cardiovascular Disease Therapy - Antioxidant carvedilol shows promise for hypertension treatment
Cerebral Malaria - Inhibition of platelet adherence in brain protects mice against severe cerebral malaria
Chiropractic Care - Multidisciplinary therapy center opened in Broward County, Florida
Collaborations - Alliance to provide text-to-speech technology to disabled technology users
Collaborations - Icagen renews drug-discovery partnership
Constipation - Clinical study initiated for oral form of methylnaltrexone
Corporate Update - Stockholders of ALS-focused company approve reorganization
Creutzfeldt-Jakob Disease - Only one more case of vCJD in Ireland - probably
Dementia - Protein deposition may lead to synaptic dysfunction, thus progressive dementias
Diagnostic Imaging - Leukoencephalopathy progression can be followed with diffusion-weighted MRI
Embryology - Airway smooth muscle is essential for fetal lung airway formation, innervation
Embryology - Tethered filum terminale may be caused by altered expression of CD44, NOT1
Endocrinology - Cisplatin binds HSP90, inhibiting glucocorticoid and androgen receptor binding
Endocrinology - Elements that control estrogen's effects on synaptic plasticity change with age
Endocrinology - Neurothrophins use paracrine control to command neurogenesis and vessel growth
Genetic Disorders - GTF2I deletions likely underlie mental retardation in Williams syndrome
Genomics - Human chromosome 6 contains many genes relating to immunity, including HLA-B
Guillain Barre Syndrome - Campylobacter jejuni infection leads to GBS via improper antibody regulation
Head Injury - Drug company stakes future on medicines from marijuana compounds
Heat-induced Immunoreactivity - Fire fatalities with cerebral heat coagulation will have tau-reactive neurons
Hypertension - Urotensin II may be neuromodulator of blood pressure
Hypertension Therapy - Losartan treatment can improve cognitive function in geriatric hypertensives
Insulin Shock - Experimental drugs reduce neuron death in rats following insulin shock
Kidney Transplantation - West Nile virus-associated meningoencephalitis is a risk after kidney transplant
Market Trends - Market for peripheral neuropathy treatment to surpass 1.5 billion patients
Mental Health - Female Parkinson disease patients are more susceptible to depression
Metamphetamine - Beta-arrestin present in metamphetamine-treated PC12 cells
Migraine - Doctors look at "chronic daily headaches"
Migraine Headache - FDA issues approvable letter for migraine prophylaxis indication for Topamax
Morphine Addiction - The GABA(B) receptor agonist baclofen inhibits opiate-induced reward effect
Movement - Parietal cortex involved in monitoring awareness of body movements
Multiple Sclerosis - CD8+ T cells in MS types are correlated to adverse MRI lesion load features
Multiple Sclerosis - Copaxone-reactive T cells produce protein that may be neuroprotective
Multiple Sclerosis - MatchPoint to help identify causes of MS
Nausea - MGI expands Aloxi agreement with Swiss company
Nerve Damage - Investigational drug desmethyldeprenyl may facilitate nerve repair
Nerve Regeneration - Company reports successful nerve regeneration studies
Neural Ubiquitination - ZNRF proteins, presynaptic E3 ubiquitin ligases, may control neuronal synapses
Neurodegeneration - Genetics of adult-onset neuropsychiatric disease discussed
Neurodegeneration - Neurological disease gives elevated neurofilament-L levels, normally very low
Neurological Disease - Serum anti-Fas antibody levels aren't specific for amyotrophic lateral sclerosis
Neurology - Neuropsychiatric disorders are best studied using new knowledge of brain anatomy
Neuroscience - Intracerebral gene transfer protects against neurodegeneration
Neuroscience - Urinary incontinence prevalence is high in women with familial dysautonomia
Neurotoxin - Neurotoxin genes encode diverse proteins in venom of Naja sputatrix
Orthopedics - Self-management improves physical function for patients with acute low back pain
Pain Medicine - Gardens have the potential to improve health, research shows
Pain Medicine - Intrathecal sufentanil analgesia is short-lived in laboring cocaine users
Parkinson Disease - Dopaminergic stimulation linked to changes in apoptosis proteins
Parkinson Disease - Exercise increases plasma IL-10, adrenocorticotropin, endogenous morphine in PD
Parkinson Disease - Molecular pathways of neurodegeneration in Parkinson disease reviewed
Parkinson Disease - Proteome analysis providing insight into Parkinson disease
Pediatric AIDS - Children's genetic factors determine HIV progression
Personnel - Vern Loucks joins painkiller company's board of directors
Postoperative Pain - Pharmaceutical company seeks U.K. approval of DepoMorphine
Postpartum Depression - Study links lower DHA status to risk of postpartum depression
Prion Disease - Heparan sulfate appears to act in the reconformation of PrPC into prion PrPSc
Prion Disease - Therapies for transmissible spongiform encephalopathies reviewed
Proteomics - Lipophilic groups improve affinity of GM1 mimics for cholera toxin
Schizophrenia - Brain's "master molecule" produces same behavior in mice from three different drugs
Stem-Cell Research - Mesenchymal stem cells can differentiate into neuron-like cells in vitro
Stem-Cell Research - Neural stem-cell self-renewal - unlike progenitor proliferation - is Bmi-1 dependent
Stem-Cell Research - Neuronal precursors can differentiate into astrocytes
Stress - Coping behaviors linked to female chromosome
Stroke - Acetylcholinesterase activity altered after focal cerebral ischemia
Stroke - Grapes may minimize brain damage
Stroke - Smoking increases bleeding strokes among women
Stroke - Tacrolimus acts as neuroprotective agent, may reduce stroke-related brain damage
Stroke Epidemiology - Strokes more common in Europe than U.S.
Substance Abuse - Ecstasy cools down
T-Cell Activation - Specific T cells expand, nonspecific ones are depleted in response to pathogens
Temporomandibular Joint Disease - Synovial tissue, fluid from TMJ disease patients has slightly higher bradykinin
Trypanosoma Cruzi - T. cruzi meningoencephalitis may be inhibited by anti-VLA-4 Ab
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