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Pain and Central Nervous System Week

Susan Hasty, Publisher

Table of Contents . . . December 15th, 2003

Non-Subscriber - Summaries Only

Related Areas: Other Issues in Pain and Central Nervous System Week | Other Publications

Brain Cancer - Study finds new clues to the origins of brain tumors

Developmental Biology - Fat molecules make bigger brains

Alzheimer Disease - New technique detects earliest signs of cognitive decline in healthy people

Brain Remodeling - Scientists discover how brain draws and re-draws picture of world

Speech Pathology - Brain activity abnormal in children with delayed speech

Stroke Mortality - More sudden deaths after left-sided stroke than after right-sided

Addiction Medicine - MK-801 attenuates cocaine induction of preprodynorphin mRNA levels

Alzheimer Disease - Amyloid plaque-forming beta-secretase BACE1 is controlled by heparan sulfate

Alzheimer Disease - Beta-amyloid released from lipid membrane by methionine oxidation

Alzheimer Disease - Caspase generates protein fragments with Smac/Diablo-like activities

Alzheimer Disease - Dehydroepiandrosterone reduces activity of BACE in stressed NT2 neurons

Alzheimer Disease - Patients learn how to stave off debilitating disease

Alzheimer Disease - Update on pharmacologic treatment of Alzheimer disease released

Alzheimer Disease - X-34 exhibits antioxidant activity in synaptosomal and neuronal systems

Anesthesia - Study explores whether new monitor helps patients recover faster

Anti-Infectives - Long-term linezolid treatment can cause toxic optic neuropathy

Atrial Fibrillation - Warfarin effective for stroke prevention

Attention Deficit/Hyperactivity Disorder - ANDA filed for generic version of Adderall

Autism - Humanoid robot to aid autism diagnosis is goal of new study

Autism - Large-scale study to try and unlock brain's mysteries

Botulism - Potent inhibitors of botulinum neurotoxin type B developed

Cardiovascular Disease Therapy - Antioxidant carvedilol shows promise for hypertension treatment

Cerebral Malaria - Inhibition of platelet adherence in brain protects mice against severe cerebral malaria

Chiropractic Care - Multidisciplinary therapy center opened in Broward County, Florida

Collaborations - Alliance to provide text-to-speech technology to disabled technology users

Collaborations - Icagen renews drug-discovery partnership

Constipation - Clinical study initiated for oral form of methylnaltrexone

Corporate Update - Stockholders of ALS-focused company approve reorganization

Creutzfeldt-Jakob Disease - Only one more case of vCJD in Ireland - probably

Dementia - Protein deposition may lead to synaptic dysfunction, thus progressive dementias

Diagnostic Imaging - Leukoencephalopathy progression can be followed with diffusion-weighted MRI

Embryology - Airway smooth muscle is essential for fetal lung airway formation, innervation

Embryology - Tethered filum terminale may be caused by altered expression of CD44, NOT1

Endocrinology - Cisplatin binds HSP90, inhibiting glucocorticoid and androgen receptor binding

Endocrinology - Elements that control estrogen's effects on synaptic plasticity change with age

Endocrinology - Neurothrophins use paracrine control to command neurogenesis and vessel growth

Genetic Disorders -  GTF2I deletions likely underlie mental retardation in Williams syndrome

Genomics - Human chromosome 6 contains many genes relating to immunity, including HLA-B

Guillain Barre Syndrome -  Campylobacter jejuni infection leads to GBS via improper antibody regulation

Head Injury - Drug company stakes future on medicines from marijuana compounds

Heat-induced Immunoreactivity - Fire fatalities with cerebral heat coagulation will have tau-reactive neurons

Hypertension - Urotensin II may be neuromodulator of blood pressure

Hypertension Therapy - Losartan treatment can improve cognitive function in geriatric hypertensives

Insulin Shock - Experimental drugs reduce neuron death in rats following insulin shock

Kidney Transplantation - West Nile virus-associated meningoencephalitis is a risk after kidney transplant

Market Trends - Market for peripheral neuropathy treatment to surpass 1.5 billion patients

Mental Health - Female Parkinson disease patients are more susceptible to depression

Metamphetamine - Beta-arrestin present in metamphetamine-treated PC12 cells

Migraine - Doctors look at "chronic daily headaches"

Migraine Headache - FDA issues approvable letter for migraine prophylaxis indication for Topamax

Morphine Addiction - The GABA(B) receptor agonist baclofen inhibits opiate-induced reward effect

Movement - Parietal cortex involved in monitoring awareness of body movements

Multiple Sclerosis - CD8+ T cells in MS types are correlated to adverse MRI lesion load features

Multiple Sclerosis - Copaxone-reactive T cells produce protein that may be neuroprotective

Multiple Sclerosis - MatchPoint to help identify causes of MS

Nausea - MGI expands Aloxi agreement with Swiss company

Nerve Damage - Investigational drug desmethyldeprenyl may facilitate nerve repair

Nerve Regeneration - Company reports successful nerve regeneration studies

Neural Ubiquitination - ZNRF proteins, presynaptic E3 ubiquitin ligases, may control neuronal synapses

Neurodegeneration - Genetics of adult-onset neuropsychiatric disease discussed

Neurodegeneration - Neurological disease gives elevated neurofilament-L levels, normally very low

Neurological Disease - Serum anti-Fas antibody levels aren't specific for amyotrophic lateral sclerosis

Neurology - Neuropsychiatric disorders are best studied using new knowledge of brain anatomy

Neuroscience - Intracerebral gene transfer protects against neurodegeneration

Neuroscience - Urinary incontinence prevalence is high in women with familial dysautonomia

Neurotoxin - Neurotoxin genes encode diverse proteins in venom of Naja sputatrix

Orthopedics - Self-management improves physical function for patients with acute low back pain

Pain Medicine - Gardens have the potential to improve health, research shows

Pain Medicine - Intrathecal sufentanil analgesia is short-lived in laboring cocaine users

Parkinson Disease - Dopaminergic stimulation linked to changes in apoptosis proteins

Parkinson Disease - Exercise increases plasma IL-10, adrenocorticotropin, endogenous morphine in PD

Parkinson Disease - Molecular pathways of neurodegeneration in Parkinson disease reviewed

Parkinson Disease - Proteome analysis providing insight into Parkinson disease

Pediatric AIDS - Children's genetic factors determine HIV progression

Personnel - Vern Loucks joins painkiller company's board of directors

Postoperative Pain - Pharmaceutical company seeks U.K. approval of DepoMorphine

Postpartum Depression - Study links lower DHA status to risk of postpartum depression

Prion Disease - Heparan sulfate appears to act in the reconformation of PrPC into prion PrPSc

Prion Disease - Therapies for transmissible spongiform encephalopathies reviewed

Proteomics - Lipophilic groups improve affinity of GM1 mimics for cholera toxin

Schizophrenia - Brain's "master molecule" produces same behavior in mice from three different drugs

Stem-Cell Research - Mesenchymal stem cells can differentiate into neuron-like cells in vitro

Stem-Cell Research - Neural stem-cell self-renewal - unlike progenitor proliferation - is Bmi-1 dependent

Stem-Cell Research - Neuronal precursors can differentiate into astrocytes

Stress - Coping behaviors linked to female chromosome

Stroke - Acetylcholinesterase activity altered after focal cerebral ischemia

Stroke - Grapes may minimize brain damage

Stroke - Smoking increases bleeding strokes among women

Stroke - Tacrolimus acts as neuroprotective agent, may reduce stroke-related brain damage

Stroke Epidemiology - Strokes more common in Europe than U.S.

Substance Abuse - Ecstasy cools down

T-Cell Activation - Specific T cells expand, nonspecific ones are depleted in response to pathogens

Temporomandibular Joint Disease - Synovial tissue, fluid from TMJ disease patients has slightly higher bradykinin

Trypanosoma Cruzi -  T. cruzi meningoencephalitis may be inhibited by anti-VLA-4 Ab

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