Susan Hasty, Publisher
Table of Contents . . . January 12th, 2004
Non-Subscriber - Summaries OnlyRelated Areas: Other Issues in Pain and Central Nervous System Week | Other Publications
Pain Medicine - Treatment targets migraines, head and neck pain
Amyloidotic Polyneuropathy - A rapid serological assay can identify amyloidogenic transthyretin variants
Analgesics - Conotoxin MVIIA and thioredoxin fusion protein has analgesic activity
Anxiety Disorder - Lexapro receives FDA approval for generalized anxiety disorder
Arthritis - FDA grants approval for Indomethacin capsules
Autoimmune Disease - Familial stiff-person syndrome may have GAD65 autoantibody, differing symptoms
Bipolar Disorder - Brain area that regulates emotions is smaller in manic-depressive people
Botulinum Toxin - Rapid botulinum toxin type B microsensor developed
Brain Cancer - New MRI contrasts discern response to gene therapy in rodent glioma models
Brain Tumors - TRAIL triggers apoptosis in human malignant glioma cells
Carbon Monoxide Poisoning - CO poisoning is due to ROS affecting neurons; hypothermia can reduce the damage
Stroke - New understanding of why brain cells die after stroke will lead to new treatments
Cell Signaling - Piccolo proteins pique neurons
Central Nervous System - Protein tyrosine phosphatases in nervous system reviewed
Chemical Warfare - Leukocyte DNA fragmentation may be diagnostic for low exposure to nerve agent
Collaborations - Lexicon enters neuroscience alliance for drug development
Creutzfeldt Jakob Disease - First case of mad cow found in U.S.
Creutzfeldt-Jakob Diseaes - Rogue protein lurks behind mad cow infection in cattle and humans
Cryptococcosis - Cryptococcus neoformans capsule formation can be blocked by RNA interference
Depression - Study: Patients treated with Paxil CR are less likely to discontinue therapy
Dermatology - SLURP-1 is an epidermal neuromodulator; its gene is mutated in Mal de Meleda
Drug Delivery - Company announces newly patented lorazepam nasal delivery system
Developmental Biology - Single gene plays key role in neural tube defects
Drug Development - 5HTIA serotonin receptor agonists suppress P. falciparum growth
Eating Disorders - Changes in the noradrenergic system underlie anorexia nervosa risk
Endocrinology - The enzyme aromatase helps estradiol to protect the brain from degeneration
Environmental Toxins - Low-mercury choices for fish a challenge
Epilepsy - Gamma-aminobutyric acid receptor expression increased in epilepsy
Familial Amyloid Polyneuropathy - VLDL/chylomicron plays role in amyloid formation
Finance - Drug discovery company announces 2003 net loss of $3,925,000
Finance - Hearing care company completes $7.5 million financing
Finance - Pharmaceutical firm reports lower revenues, provides clinical update
Geriatrics - Ginkgo biloba prevents memory deficits in Alzheimer disease animal models
Familial Amyloid Polyneuropathy - Nerve degeneration in familial amyloid polyneuropathy studied
HIV/AIDS Therapy - Early antiretroviral treatment is neuroprotective in vertically infected children
HIV/AIDS Therapy - Methylnaltrexone inhibits opioid-mediated HIV macrophage infection
Headache - Company begins clinical trial in migraine, appoints chief medical officer
Heat Shock Proteins - Neuroprotection due to HSP induction may occur with geranylgeranylacetone
Herpes Zoster - Wolf isotopic response can be granuloma annulare at herpes zoster wound site
Hip Fracture - Interventions needed to promote adoption of evidence-based acute pain management
Immunoglobulins - Cocaine-binding scFv antibody can be made in E. coli, purified, freeze-dried
Intracerebral Hemorrhage - IL-10 release following intracerebral hemorrhage varies depending on hemisphere
Kidney Transplantation - Nonmyeloablative SCT from kidney donor can resolve PTLD
Market Forecast - Report: G protein-coupled receptors have significant potential
Guillain-Barre Syndrome - galE gene in campylobacters linked to Guillain-Barre syndrome
Memory Function - VEGF is a prerequisite for exercise-induced hippocampal neurogenesis
Memory Improvement - Concord grape juice improved memory, neuromotor skills in animal study
Meningitis - CDC: Vaccine shortage likely
Menopause - Early hormone replacement is fundamental to limiting cognitive decline
Mergers and Acquisitions - Acquisition to advance treatment of viral diseases and neurological disorders
Multiple Sclerosis - A whole genome screen reveals 33 genes associated with multiple sclerosis
Multiple Sclerosis - A whole genome screen reveals five genes associated with multiple sclerosis
Multiple Sclerosis - Neutralizing antibodies to IFN beta-1b therapy for relapsing-remitting MS may affect outcome
Multiple Sclerosis - Vascular changes prevail in disorders that host chronic neuroinflammation
Muscular Diseases - Neurons in Duchenne, myotonic dystrophy have excess non-cholinergic synapses
Memory - Mad cow mechanism may be integral to storing memory
Neuronal Cell Death - Glutamate neurotoxicity may be blockable by a calcineurin-inhibiting peptide
Neuronal Synapse - Interneuronal synapse formation, actin restructuring involves cadherins, nectins
Neuropathy - Apolipoprotein E is a nerve recovery and neovascularization intermediary
Neuroscience - Estrogen protects against methamphetamine-induced neurological insult
Neuroscience - Microangiogenesis facilitates parkinsonism
Neuroscience - Novel hyaluronan-based biomaterials support nerve repair
Ophthalmology - Genetic basis for fashion crime?
Pain Medicine - Desflurane general anesthesia alters hepatic venous pressure
Parkinson Disease - DJ-1 gene polymorphism not linked to Parkinson disease
Parkinson Disease - Molecular chaperones protect parkin from oxidative stress inactivation
Alzheimer Disease - Alzheimer disease treatment slows progression of cognitive decline in study
Prion Disease - Creutzfeldt-Jakob disease can occur as a result of an insertion in the PRNP gene
Proteomics - O-GlcNAc plays role in diabetes, cancer, and neurodegeneration
Receptor Studies - LDL receptor-related protein controls blood-brain barrier permeability
Rett Syndrome - MeCP2, the mutated transcription factor in Rett syndrome, alters nerve synapses
Substance Abuse - Individuals with eating disorders more likely to abuse alcohol and drugs
Sudden Infant Death - The cytokine interleukin-1beta is highly expressed in SIDS brains
Sudden Infant Death Syndrome - Neurons of dorsal motor vagal nucleus show hypoxia-related marker in SIDS brains
Urinary Tract Dysfunction - Sacral neuromodulation beneficial for patients with neurogenic urinary retention
Alzheimer Disease - Down syndrome study reveals possible method for detecting initial stages of AD
Alzheimer Disease - Scope of Phenserine trial; sub-study to include brain scans
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