Creutzfeldt-Jakob Disease

Artificial prions created

Published in Pain and Central Nervous System Week, April 5th, 2004

The culprit behind mad cow disease (i.e., bovine spongiform encephalopathy) is the most infamous mammalian form of prions. Prions are misfolded proteins that are capable of growing, replicating, and being passed on to daughter cells - that is, they are by themselves heritable.

Beyond their disease manifestation, prions also occur naturally in some organisms (such as yeast) and may play important roles in their growth and development. Now, Lev Osherovich and colleagues at the University of California, San Francisco have identified the amino acid sequences that allow prions to aggregate and replicate - and thereby pass through generations of cells - and prove this by...

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Source: Pain and Central Nervous System Week (2004-04-05)

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