Published in Pain and Central Nervous System Week, May 17th, 2004
"Hepatic clearance of chemotherapy drugs is increased by many antiepilepsy drugs." New-onset "seizures in children on chemotherapy are treated with gabapentin, a nonhepatic enzyme inducer," at the authors' institution. "The charts of all children given gabapentin for seizures were reviewed," wrote scientists at St. Jude Children's Hospital.
"At a median follow-up of 34 months, seizures were controlled in 74% of 50 children given gabapentin monotherapy as initial treatment: 91% of the leukemia group, 57% of the brain tumor group, and 75% of the other tumor group. Seizures were controlled...
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