Anticancer Therapy
Neurotoxicity of anticancer agents tested in microglial cell cultures
Published in Pain and Central Nervous System Week, May 17th, 2004
"Toxicity of anticancer agents on normal neural cells during chemotherapy of primary or secondary brain tumors is a clinical problem of increasing relevance and concern. In this perspective, primary cultures of rat cortical microglia as an in vitro paradigm of normal glia" was used "to investigate the neurotoxicity of anticancer agents," wrote scientists in Italy.
"The effects of two compounds frequently used for treatment of brain tumors, methotrexate (MTX) and temozolomide (TMZ), were compared to those of a known microglial activator, bacterial lipopolysaccharide (LPS); cell...
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