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Pain and Central Nervous System Week

Susan Hasty, Publisher

Table of Contents . . . August 23rd, 2004

Non-Subscriber - Summaries Only

Related Areas: Other Issues in Pain and Central Nervous System Week | Other Publications

Diabetic Neuropathy - Supporting sensory neurons may aid diabetic patients

Drug Delivery - Transdermal permeation of synthetic cannabinoids determined

Epilepsy - Effects of vagus nerve stimulation on cortical excitability determined

Knee Replacement - Obdurator nerve block enhances femoral nerve block analgesia

Neuroscience - Hepatitis A virus infection sparks acute disseminated encephalomyelitis

Addiction Medicine - Novel model improves assessment of methadone compliance

Adolescent Health - Many adolescent girls experience headache, stomachache, back pain and fatigue

Alzheimer Disease - "Tangled" rat provides landmark experimental model

Alzheimer Disease - Early clinical treatment can halt progression of AD

Alzheimer Disease - HIV survivors vulnerable to dementia?

Alzheimer Disease - Immune therapy "untangles" Alzheimer plaques

Alzheimer Disease - Mice overexpressing A-beta are incomplete model of Alzheimer disease

Alzheimer Disease - New drug treats both symptoms and cause of Alzheimer disease

Alzheimer Disease - Oakland facility may have found possible contributing cause of AD

Alzheimer Disease Therapy - Vaccine reduces A-beta levels in non-human primate

Amyotrophic Lateral Sclerosis - Orphan drug designation granted by FDA for drug candidate to treat ALS

Antiretroviral Therapy - Mental illness and sociological factors impact antiretroviral adherence

Arrhythmias - Diffuse T-wave inversions can occur with electroconvulsive therapy

Arthritis - A novel therapy of murine collagen-induced arthritis with soluble T1/ST2

Autism - Physiological treatment center uses LifeShirt to measure signs of autism

Awards - 2004 Alzheimer Award presented to Lester I. Binder

Bovine Spongiform Encephalopathy - Human mad cow infection may be more widespread than previously thought

Brain Aneurysm - 3D CT cisternogram useful for preoperative contour evaluation

Brain Cancer - 3-D irradiation of brain cancer in children can spare cognitive functions

Brain Cancer - 3-D irradiation of brain tumors in children spares IQ, memory

Brain Cancer - Clusters of alterations on PIK3CA gene found in brain cancers

Brain Cancer - Small molecule inhibitors thwart glioma growth

Brain Tumor - Nutritional rehabilitation may help growth in pediatric brain cancer patients

Brain Tumor - Permanently implanted device used for intratumoral chemotherapy in rat brain

Business & Finance - CHRONOGESIC maker reports increased Q2 revenue, updates development programs

Business & Finance - Medical device company announces financial results

Business & Finance - Neuroscience-based biotech updates Q2, reports $118 million net loss

Central Nervous System - Estrogen facilitates neurite extension via ApoE in mouse cortical neurons

Cerebral Palsy - United Cerebral Palsy extends resources, services through MetDESK

Cholesterol - Lipid association releases findings attitudes about over-the-counter statins

Collaborations - Target & marker discovery collaboration with Merck to focus on AD

Depression - Boomers warned to watch for signs of elderly depression

Depression - Depression traced to overactive brain circuit

Depression Therapy - Perospirone may enhance fluoxetine efficacy

Drug Abuse - Relationship between psychiatric disorders and addiction explored in report

Drug Addiction - Cocaine does not affect dopamine synthesis in rats

Drug Development - Drug developer receives approval for drug bringing 2004 total approvals to 10

Drug Development - Enrollment completed in clinical trial for Gaucher disease

Drug Development - Manhattan Pharmaceuticals, Inc., to file for IND for lingual spray sedative

Drug Development - Novel selective GSK-3beta inhibitors synthesized

Environmental Health - Hardness of drinking water studied as cardio-, cerebrovascular disease risk

Environmental Toxins - Study finds high mercury in lake fish

Epilepsy - Patent application filed for epilepsy compound

Erectile Dysfunction - FDA clears device for erectile dysfunction

Finance - Drug development company reports 2004 second quarter results

Finance - Neuromodulation device maker reports net income increases 48%

Finance - Pharma company specializing in neurodegenerative diseases secures financing

Finance - Strong second quarter for pharmaceutical company, 2004 to be very good year

Geriatrics - Use of statin drugs for Alzheimer treatment gaining wide attention

HIV/AIDS Infection - HIV/AIDS knowledge does not translate into perceived risk

HIV/AIDS Research - Cerebral synthesis of complement factors strongly upregulated in SIV infection

HIV/AIDS Research - HIV Tat protein prevents long-term potentiation in hippocampal CA1 region

HIV/AIDS-Associated Dementia - HIV associated neurodegeneration requires p53 in neurons and microglia

Headache and Migraine - Phase II trials for use of PreHistin to prevent atopic migraine begin

Heart Attack Prevention - Aspirin resistance test now available nationwide

Immunology - FDA accepts NDA for Xibrom

Legal Issues - Suit alleges Zoloft maker concealed evidence, misled doctors about drug safety

Lung Cancer - ADAM9 overexpression correlates with brain metastasis in NSCLC

Medical Marijuana - Medical marijuana initiative sparks debate

Mergers & Acquisitions - Imaging company acquires cardiovascular, neurovascular disease specialist

Multiple Sclerosis - FDA accepts BLA for ANTEGREN

Multiple Sclerosis - T-cell reactivity to immunodominant PLP peptides higher in women than men

Multiple Sclerosis Therapy - Daclizumab effective in patients failing to respond to interferon-beta

Myasthenia Gravis - IL-10-modified dendritic cells protect against autoimmune myasthenia gravis

Narcolepsy - Trial studying daytime sleepiness associated with narcolepsy progressing

Neurodegeneration - VEGF and bone marrow transplantation treat newborn mice with enzyme deficiency

Neurology - Hybrid neural system improves study of neuronal currents

Neuroscience - Brain trauma heightens TGFbeta RII expression on endothelial cells

Neuroscience - Cadmium blocks GABA-activated ion currents by raising intracellular Ca level

Neuroscience - Genomic effects of environmental enrichment characterized

Neuroscience - Orbit/MAST acts downstream of Abl in mediating axon guidance

Neuroscience - St. John's wort constituent stimulates hippocampal acetylcholine release

Neuroscience - Transdermal nitroglycerin safe, effective for subarachnoid hemorrhage treatment

Obstetrics - Maternal T3 and T4 levels in early pregnancy affect fetal brain development

Oligodendroglioma - Utility of immunohistochemistry in differential diagnosis determined

Osteoarthritis - Common drugs are ineffective after 2 weeks

Otology - Hearing where it's at: how humans and gerbils learn to locate sound

Pain Medicine - Diagnosis of painful total knee arthroplasty reviewed

Pain Medicine - Pupillary effects of opioids determined

Painkiller Addiction - West Virginia official says federal data on painkiller addiction not accurate

Panic Disorder - Gene polymorphism associated with panic disorder with agoraphobia

Parkinson Disease - New technologies aid in discovery of novel gene transcripts

Parkinson Disease - Screening tool could prevent wrong patients from receiving brain surgery

Perception - Study explains spatial orientation differences between sexes

Personnel - Biopharmaceutical company announces executive appointments

Personnel - CORLUX maker appoints David L. Mahoney to board of directors

Preeclampsia - Cytotoxic edema may evolve differently from pattern seen in cerebral infarction

Prion Disease - Prions found in skeletal muscle cells and papillae in the tongue

Prion Diseases - Synthetic prion causes neurological disease in mice

Restructuring - Medical technology company announces restructuring plans, reports results

Schizophrenia - Study links ACP-104 to improved cognition in schizophrenia patients

Spasticity Therapy - Rights to Zanaflex acquired from Elan

Spinal Cord Ischemia - Delta-opioid agonist SNC80 preserves rat hind-limb function

Spinal Cord Regeneration - Novel techniques promote recovery from spinal cord injury

Stem Cell Research - Amyloid-beta peptide has positive and deleterious actions in neurogenesis

Stem Cell Research - At single cell level ESC-derived neurons integrate into the host brain circuitry

Stem Cell Research - Chronic ethanol consumption transiently reduces neural stem cell proliferation

Stem Cell Research - Neural stem cells survive, migrate, differentiate in pre-clinical stroke study

Stem Cell Research - Neuronal cells can be specifically generated from bone marrow stromal cells

Stroke - Clinical targets show promise for minimizing effects of stress hormones

Stroke - Green mamba snake venom hormone may cause "second stroke"

Stroke - Statins decrease stroke incidence in people with coronary heart disease

Stroke - Stroke related and unrelated to pregnancy examined in reproductive-age women

Stroke Therapy - AM-36 neuroprotective in murine stroke model

Substance Abuse - Genes may be central to cocaine addiction

Tinnitus - Patients need not suffer in silence

Tobacco Use - Nicotine inhibits sulpiride-induced dopamine release in nucleus accumbens

Traumatic Brain Injury - New research calls for schools to be more aware of head injuries

Vertigo - New research explains lag in onset of common type of vertigo

Virology - How a killer virus emerged: changed environment + mutation = evolution

Wound Care - A little help from friends makes wounds heal faster

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