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Pain & Central Nervous System Week

Susan Hasty, Publisher
Table of Contents . . . February 21st, 2005
Non-Subscriber - Summaries Only
Related Areas: Other Issues in Pain & Central Nervous System Week | Other Publications

Addiction Medicine - Controversial drug shown to act on brain protein to cut alcoholism

Amyotrophic Lateral Sclerosis - Pattern of outflow to muscles may be similar to chronological changes at neurons

Amyotrophic Lateral Sclerosis - Wisconsin scientists grow critical nerve cells

Pain Medicine - Study examined the nature of chest pain

Transient Ischemic Attack - TIA patients receive less aggressive attention than those with stroke

Activin Receptors - Receptor complexes studied, utility of a cell-free system revealed

Addiction Medicine - Urokinase plasminogen-type activator elicits behavioral changes in abuse models

Alcohol - Muscle weakness, arrhythmias and LV dysfunction are chronic effects of alcohol

Alcohol Use - Genes influence adolescent alcohol consumption

Alcohol Use - Many alcohol-dependent HIV patients need assistance adhering to medications

Alzheimer Disease - Amyloid peptide studied, interactions with membranes revealed

Alzheimer Disease - Amyloid precursor protein studied, efficacy of clioquinol clarified

Alzheimer Disease - Autoantigen vaccination protects against aggregated beta-amyloid toxicity

Alzheimer Disease - Enrollment for approved study of implant to treat Alzheimer disease completed

Alzheimer Disease - Group urges steps to prevent wandering during cold weather

Alzheimer Disease - Nanoscale diagnostic sets sights on AD

Alzheimer Disease - New test might help detect Alzheimer disease in early stages

Alzheimer Disease - Pharma company announces interim data for proof of principle study of PYM5008

Alzheimer Disease - Presenilin-1 and gamma-secretase studied, role of fatty acids revealed

Alzheimer Disease - Progress made toward a more targeted treatment of AD

Alzheimer Disease - Research company receives funds for Alzheimer and Parkinson research

Alzheimer Disease - Test may help detect AD earlier

Amyloid Proteins - Beta-amyloid levels studied in mice, influence of age revealed

Amyotrophic Lateral Sclerosis - New findings in the area of amyotrophic lateral sclerosis detailed

Amyotrophic Lateral Sclerosis - Spinal cord apoptosis present in LDV-induced murine ALS model

Anesthesia - Landiolol is safe and effective during maintenance electroconvulsive therapy

Anoxia - Sodium influx pathways in hippocampal neurons studied, role of anoxia revealed

Antidepressants - Effects of fluoxetine on subcortical dopamine neurotransmission determined

Antidepressants - Effects of imipramine and citalopram on cortical gene expression determined

Apoptosis - TRAF6 essential in mediating p75 signal transduction/apoptosis induction

Asthma - Study proves effectiveness of Pulmicort

Atherosclerosis - Volunteers with PAD needed to test dietary supplement's effect on leg pain

Autism - Monkey "pay-per-view" study could aid understanding of autism

Awards - Foundation announces recipients of annual Wiley Prize in Biomedical Sciences

Axonal Degeneration - Endogenous erythropoietin mediated pathway prevents axonal degeneration

Biochemistry - Ryanodine receptor isoform studied, putative calcium binding motifs clarified

Biomedical Engineering - Device company to launch fusion system for lower back pain

Brain Cancer - Gene used in brain development can cause childhood brain cancers

Brain Cancer - Invasive brain tumors express high levels of endosialin

Brain Trauma - Evaluation of traumatic brain injury in adults reported

Breast Augmentation - Local ketorolac and bupivacaine are effective against postoperative pain

Breast Cancer - Study: Femara provides survival advantage vs. tamoxifen in adjuvant treatment

Business & Finance - Companies form Advanced Spinal Technologies to market spine adjustment device

Business & Finance - Science-based pharmaceutical company reports Q4, full-year 2004 results

Business Update - Cardinal Health, Aricept maker ink multiyear distribution service agreement

Business Update - Drug delivery systems developer announces MCO contracts for ON-Q PainBuster

Business Update - GenData changes name

Business Update - Neuroscience corporation announces name change

Business Update - Phototherapy device manufacturer partners with Extendicare Health Services

Business Update - VNS developer submits response to FDA warning letter

COX-2 Inhibitors - Cell model was useful to study effects of COX-2 inhibitors on cell oxidants

Cancer Therapy - Study shows troubling wide variations in brain cancer treatment

Carbon Monoxide Illness - Dozens treated after carbon monoxide leak at Canadian hockey rink

Cardiac Hypertrophy - Normal cardiac growth may be cofactor in development of genetic cardiomyopathies

Cardiology - Injecting atropine during dobutamine stress ECG safely decreases test duration

Cardiology - New findings impact diagnostic, therapeutic strategies of sudden death syndromes

Cardiology - Researchers report details of new studies and findings in the area of cardiology

Cardiology - Studies focused on cardiac function in Trypanosoma cruzi-infected mice

Cardiomyopathy - Study investigated the mechanisms of apoptosis induced by high-dose alcohol

Cardiovascular Research - Fatigue is associated with CV disease, may not be influenced by genetic factors

Carpal Tunnel Syndrome - One-year study finds local steroid injection as effective as surgery

Cell Biology - Scientists reveal cells' "energy factories" linked to cancer

Cerebral Oxygenation - Acute normovolemic hemodilution can lead to a reduction in cerebral oxygenation

Choledochal Cyst - Obstetricians should be familiar with choledochal cyst

Chronic Heart Failure - Trials shed light on using angiotensin receptor blockers to treat heart failure

Clinical Trials - Neuro-inflammatory disease drug approved for phase 1 clinical development

Cochlear Implants - Working memory strongly affects lexical, grammatical development in children

Collaborations - Cardiology-device company signs agreement for production of magnetic guidewires

Collaborations - Joint stem-cell research program launched

Colon Cancer - Research in colorectal cancer presented at symposium

Colorectal Cancer - Avastin plus FOLFOX4 chemotherapy regimen clinical trial results reported

Congestive Heart Failure - Rheumatoid arthritis linked to excess risk of congestive heart failure

Coronary Artery Disease - HR variability may not be cause of CV morbidity in patients with panic disorder

Creutzfeldt-Jakob Disease - Diffusion-weighted MRI can diagnose human "mad cow" early

Creutzfeldt-Jakob Disease - Group urges governments to close dangerous loopholes in animal feed rules

Creutzfeldt-Jakob Disease - Prion protein instrument decontamination studied, PrPSc detachment clarified

Critical Care Medicine - Distribution of intubation-related lidocaine assessed in brain-dead patients

Dementia - Cardiovascular risk factors in midlife linked to risk of dementia

Diabetic Neuropathy - Erythrocytic sorbitol in diabetes correlates with plasma glucose levels

Diagnostic Imaging - Q-maps from MRI may characterize tumor vascularization

Disease Associations - Alpha-synuclein studied, distribution and Lewy body relationship revealed

Disease Associations - Batten disease studied, requirements for targeting of CLN3 protein clarified

Disease Associations - Prefrontal cortex studied, influence of nicotine and smoke exposure revealed

Disease Associations - Prion protein toxicity studied, translocation-medicated protection revealed

Disease Associations - Structure of LIS1 analyzed, complex with PAF-acetylhydrolase shown

Disease Control - Report published on most prevalent, costly diseases in U.S.

Dopa-Responsive Dystonia - Diagnostic value of phenylalanine loading clarified

Drug Development - Biopharmaceutical company initiates trials for antidepressant

Drug Development - Pathway profiler service for viewing cellular responses introduced

Drug Development - Psychotropic effects of COX-2 inhibitors reported

Drug Development - U.S., European regulatory submissions made for Humira

Duchenne Muscular Dystrophy - Biopharma company granted orphan drug designation by FDA for PTC124

Electrophysiological Tests - Electrophysiologic investigations provide a window into cerebral function

Embryonic Stem Cell Research - Ceramide-induced apoptosis eliminates residual pluripotent EBCs after SCT

Endocrinology - New findings in the area of endocrinology described

Epilepsy - Atkins Diet may prove beneficial for seizure reduction

Fatigue - Fatigue diagnoses show overall decrease in the UK

Fibrosis - Review provides information on fibrosis and small bowel carcinoid tumors

Finance - Angina-focused company reports strong Q4 and 2004 results

Finance - Biopharma company announces financial results with positive outlook

Finance - Dartmouth awarded $21.8 million NSF grant

Finance - Dental products company reports record sales and earnings for Q4 and full year

Finance - Medical device company reports 101% increase in fourth quarter revenue

Finance - Pharma company completes $43 million series C financing

Finance - Pharma company receives milestone payment from Bausch & Lomb

Gastroenterology - Spontaneous activity and modulation isolated from guinea-pig stomach antrum

Gene Expression - Glycolysis genes are ubiquitously overexpressed in 24 cancer classes

Gene Expression - Myeloid leukemic cells express genes expressed in normal nonhematopoietic tissue

Genomics - Polymorphism might contribute to increased risk of coronary artery disease

Genomics - Researchers tout ability of genetic tests to avoid bad drug reactions

Genomics - Study identified biochemical and genetic defect in L-2-hydroxyglutaric aciduria

Geriatrics - Article examines increased risk of death in elderly surviving spouses

Growth Factors - Craniofacial patterning studied, role for fibroblast growth factors revealed

Gynecomastia - Neurofibroma of the breast found in a boy

HIV/AIDS Pathogenesis - HIV-1 gp120 reduces brain-derived neurotrophic factor levels

HIV/AIDS-Related Dementia - Astrocyte specific viral strains identified in HIV dementia

HTLV-1 - HTLV-1 infection may have role in mixed connective tissue disease pathogenesis

Health Promotion - Jeans too tight? University study shows 50% of adults can blame their genes

Hearing Loss - Modifier genes trigger phenotypic expression of a deafness-linked mutation

Heart Disease - Biopharmaceutical company releases results of clinical studies in hypertension

Hereditary Hemorrhagic Telangiectasia - Hepatic artery embolization effective for HHT patients with hepatic involvement

Huntington Disease - Drug treatment promising for halting nerve death

Hypertension - Article stresses importance of focus on lowering systolic blood pressure

Hypertrophic Cardiomyopathy - ECGs should extend into midlife in families with hypertrophic cardiomyopathy

Imaging - Dobutamine-CMR can assess risk levels for coronary events with high accuracy

Information Technology - Software company delivers web-based platform for spinal cord injury network

Ischemia - Treadmill exercise may facilitate recovery after ischemic cerebral injury

Lipid Studies - Database contains results from whole-genome scans of lipid-related phenotypes

Lipid Studies - Study investigated new variants of the apoB(4372-4392) peptide

Lipids - Review compares lipid homeostatis through liver X and thyroid hormone receptors

Lipoproteins - Protein kinase translocation studied, role of apolipoprotein revealed

Longevity - Think fast: reaction time and IQ may predict long life

Lupus - Innovative research receives increased funding

Memory - Long-term memory recall studied, lack of protein synthesis clarified

Mental Health - 5-HT1A receptor genotypes regulate a patient's response to antidepressants

Mental Health - Couples feed off each other's depressive symptoms

Mental Health - Inability to modulate affect is associated with many common mood disorders

Mental Health - Study: Facial trauma patients' need for mental health, social services is unmet

Mergers & Acquisitions - Acquisition of Neopharma AB by Swedish pharmaceutical company completed

Mergers & Acquisitions - Medical laboratory acquires pharmaceutical company

Mergers & Acquisitions - Medical technology company acquires Navion Biomedical Corporation

Migraine - New study confirms effectiveness of nasal spray for migraine treatment

Migraine Headaches - European patent issued for MT 400 technology for treatment of migraine

Migraine Therapy - Sumatriptan tablets are effective for menstrually associated migraine

Myopathy - Common genes separate focal myositis cases from systemic disease

Nanotechnology - Dendritic enters three-way deal to commercialize nanotechnology

Neck Pain - Incomplete resolution of symptoms is a pain in the neck, especially for women

Neural Stem Cell Research - Neural stem cell generation of dopaminergic neurons is enhanced by Bcl-X-L

Neuritogenesis - Neuritogenesis analyzed, role of ubiquitin ligase regulation of FEZ1 revealed

Neurodegeneration - Chronic complex-induced neurodegeneration studied, distinct mechanisms revealed

Neurodegeneration - Researchers' findings advance neurodegeneration research

Neurofibromatosis - Inflammatory cells highly promising target in NF 1

Neurogenesis - BM stromal cells differentiate into neurons via direct contact with brain tissue

Neurogenesis - Sensory cranial placode neurogenesis studied, early role of two genes revealed

Neurology - Influences of alcohol studied, role of protein kinase signaling revealed

Neuromuscular Disease - Many patients with amyotrophic lateral sclerosis bear Hfe gene mutations

Neuroscience - 19th Gamma Knife center opens in Tennessee

Neuroscience - ATPase of cerebral synaptosomes studied, effects of aluminium and lead revealed

Neuroscience - Basal taurine release in rat striatum measured by microdialysis

Neuroscience - Ca(v)2.1 Ca²⁺ channels studied, dose-dependent modulated inhibition revealed

Neuroscience - Dendritic spine shrinkage studied, role of synapse depression revealed

Neuroscience - Glucocerebrosidase mutations may correlate with the onset of parkinsonism

Neuroscience - Immunoassay enables rapid assessment of cGMP in glial cell cultures

Neuroscience - In vitro model of cold-induced astrogliosis developed

Neuroscience - MAPK/ERK studied, role in necrotic neuronal death revealed

Neuroscience - NMDA receptor kinetics studied, role of NR2A subunit dephosphorylation revealed

Neuroscience - Neurosteroid binding analyzed, site within GluR2-S1S2 domain identified

Neuroscience - New findings in neuroscience described

Neuroscience - New findings in the area of neuroscience described

Neuroscience - New research in the area of neuroscience detailed

Neuroscience - Nitric oxide inhibition in rat medial preoptic area impairs copulation

Neuroscience - Orexin neurons studied, role of current in neuron activity clarified

Neuroscience - Orexin plays key role in food anticipatory activity

Neuroscience - P-glycoprotein studied, inhibitory role in brain entry of drugs revealed

Neuroscience - Prion neurotoxicity studied, role of glycosylphosphatidylinositols revealed

Neuroscience - Protein kinase C isoforms regulate activity of human choline acetyltransferase

Neuroscience - Recent findings in neuroscience described

Neuroscience - Single-trial tasks significantly modulate hippocampal genes in rats

Neuroscience - TRIP8b has possible role in regulation of HCN channel density

Neuroscience - The low-density lipoprotein receptor gene has no linkage to migraine headache

Neuroscience - Vanilloid and endocannabinoid receptors coexpressed in brain endothelium

Neurosurgery - Combined minimally invasive techniques effective for deep ICH resolution

Nicotine Addiction - Smoking causes cognitive impairment in adolescents

Nucleoscience - alpha-Synuclein has little influence on proteasome function

Obsessive-Compulsive Disorder - Nicotine treatment of OCD shows promise

Obstetrics - Choose MRI for diagnosing pregnant women with abdominal pain

Obstructive Sleep Apnea - New sleep apnea at-home prescreening test introduced

Obstructive Sleep Apnea - Obstructive sleep apnea and restless legs triggered by genes

Ophthalmology - Optic chiasm formation analyzed, requirement for Foxd1 demonstrated

Osteoarthritis - Synthetic neuropeptide-active cream for osteoarthritis reduces pain, study shows

Osteoid Osteoma - Rofecoxib effective for pain caused by osteoid osteoma

Oxidative Stress - Biochemical changes in cold-induced oxidative stress minimized tissue damage

Oxidative Stress - Ebselen protects neural cells against oxidative stress at multiple steps

Oxidative Stress - Peroxisome receptor alpha agonist studied, increased transcription revealed

Pain Management - AT-101 reclassified as therapeutic vibrator requiring 510k submission

Pain Medicine - African Americans need equal treatment for pain

Pain Medicine - FDA allows testing of extended release ibuprofen tablets

Pain Medicine - Patient recall may overrate the results of surgery for back pain

Pain Medicine - Recent findings in pain medicine described

Pain Research - ATP receptor ectodomain studied, negative behavioral residues revealed

Pain Research - Extracorporeal shock waves studied, pain-mediating properties clarified

Parkinson Disease - Alpha-synuclein fibrillation analyzed, role of rifampicin revealed

Parkinson Disease - U.K. research could lead to new treatments for Parkinson

Patents - Company wins patent relating to treatment of lower urinary tract disorders

Pediatric Pain Management - Pediatric clinical study of topical pain killer at children's center completed

Personnel - Biotech company names Rebecca Galler Robison senior director, corporate strategy

Personnel - Company focused on devices for lumbar spinal stenosis names Michael Bates CFO

Personnel - Pain-management-focused pharma adds new directors

Personnel - Tony Scullion appointed to board of Biotechnology Council of New Jersey

Pharmaceuticals - Company links genetic variation to the effect of HRT on C-reactive protein

Pharmaceuticals - Kaiser to stop dispensing painkiller Bextra

Pharmacology - Indoprofen stimulates survival motor neuron protein production

Polymyalgia Rheumatica - PMR is reversible and must be differentiated from other similar diseases

Premenstrual Dysphoric Disorder - Depression and anxiety not linked to plasma estrogen and progesterone levels

Prions - Reports add new data to prions research

Prions - Synthetic human prion protein analyzed, binding to proteinase K demonstrated

Progenitor Cells - Cortical neurons studied, transcriptional factor expression clarified

Protein Precursors - Sonic hedgehog signaling analyzed, spatial pattern revealed

Proteomics - Induction of cytokines and chemokines studied, nonrole of thrombin revealed

Proteomics - Protocadherin-gamma b1 interacts with microtubule-destabilizing protein SCG10

Proteomics - Researchers' data advance proteomics research

Rheumatoid Arthritis - Japan's regulatory body approves anti-TNF receptor to treat rheumatoid arthritis

Sexual & Reproductive Health - Human sexual behaviors exhibit a moderate link to genetic influences

Spinal Cord Injury - 'Bladder pacemaker' shows promise for people with spinal cord injury

Spinal Cord Injury - Program initiated to develop RNAi therapeutics for spinal cord injury

Stem Cell Therapy - Stem cell therapy may be used to treat neurotrauma

Stress - Increased cortisol activity was associated with less recent stress exposure

Stroke - $33M grant to support Insulin Resistance Intervention after Stroke trial

Stroke - A new notch in the Stroke Belt: Blacks in the South are most likely to die

Stroke - Migraine-sparked vision loss may increase stroke risk in women

Stroke - New competency guidelines for carotid stenting include virtual reality training

Stroke - New trial initiated in stroke prevention

Surgical Technology - Study of sealant to reduce blood loss, pain in knee arthroplasty reported

Tissue Engineering - Importance of functional innervation demonstrated in tissue engineered models

Tissue Engineering - Rotating wall vessel bioreactor generates neural tissue like constructs

Urinary Incontinence - Seratonin/norepinephrine reuptake inhibitor provides new approach to UI

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